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10.1152/ajpendo.00035.2015 http://scihub22266oqcxt.onion/10.1152/ajpendo.00035.2015 C4572452!4572452!26173457     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Endocrinol+Metab 2015 ; 309 (6): E534-45 Nephropedia Template TP {{tp|p=26173457|t=2015. Pendrin localizes to the adrenal medulla and modulates catecholamine release |pdf=|usr=}}{{26173457}} gab.com Text Pendrin localizes to the adrenal medulla and modulates catecholamine release JO: Am J Physiol Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=26173457 #FOAvip Pendrin (Slc26a4) is a Cl?/HCO3? exchanger expressed in renal intercalated cells and mediates renal Cl? absorption. With pendrin gene ablation, blood pressure and vascular volume fall, which increases plasma renin concentration. However, serum aldosterone does not significantly increase in pendrin-null mice, suggesting that pendrin regulates adrenal zona glomerulosa aldosterone production. Therefore, we examined pendrin expression in the adrenal gland using PCR, immunoblots, and immunohistochemistry. Pendrin protein was detected in adrenal lysates from wild-type but not pendrin-null mice. However, immunohistochemistry and qPCR of microdissected adrenal zones showed that pendrin was expressed in the adrenal medulla, rather than in cortex. Within the adrenal medulla, pendrin localizes to both epinephrine- and norepinephrine-producing chromaffin cells. Therefore, we examined plasma catecholamine concentration and blood pressure in wild-type and pendrin-null mice under basal conditions and then after 5 and 20 min of immobilization stress. Under basal conditions, blood pressure was lower in the mutant than in the wild-type mice, although epinephrine and norepinephrine concentrations were similar. Catecholamine concentration and blood pressure increased markedly in both groups with stress. With 20 min of immobilization stress, epinephrine and norepinephrine concentrations increased more in pendrin-null than in wild-type mice, although stress produced a similar increase in blood pressure in both groups. We conclude that pendrin is expressed in the adrenal medulla, where it blunts stress-induced catecholamine release. Twit Text FOAVip Pendrin localizes to the adrenal medulla and modulates catecholamine release ????Am J Physiol Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=26173457 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26173457 #FOAvip English Wikipedia <ref>{{Cite pmid|26173457}}</ref> Pendrin localizes to the adrenal medulla and modulates catecholamine release #MMPMID26173457 Lazo-Fernandez Y; Aguilera G; Pham TD; Park AY; Beierwaltes WH; Sutliff RL; Verlander JW; Pacak K; Osunkoya AO; Ellis CL; Kim YH; Shipley GL; Wynne BM; Hoover RS; Sen SK; Plotsky PM; Wall SM Am J Physiol Endocrinol Metab 2015[Sep]; 309 (6): E534-45 PMID26173457show ga Pendrin (Slc26a4) is a Cl?/HCO3? exchanger expressed in renal intercalated cells and mediates renal Cl? absorption. With pendrin gene ablation, blood pressure and vascular volume fall, which increases plasma renin concentration. However, serum aldosterone does not significantly increase in pendrin-null mice, suggesting that pendrin regulates adrenal zona glomerulosa aldosterone production. Therefore, we examined pendrin expression in the adrenal gland using PCR, immunoblots, and immunohistochemistry. Pendrin protein was detected in adrenal lysates from wild-type but not pendrin-null mice. However, immunohistochemistry and qPCR of microdissected adrenal zones showed that pendrin was expressed in the adrenal medulla, rather than in cortex. Within the adrenal medulla, pendrin localizes to both epinephrine- and norepinephrine-producing chromaffin cells. Therefore, we examined plasma catecholamine concentration and blood pressure in wild-type and pendrin-null mice under basal conditions and then after 5 and 20 min of immobilization stress. Under basal conditions, blood pressure was lower in the mutant than in the wild-type mice, although epinephrine and norepinephrine concentrations were similar. Catecholamine concentration and blood pressure increased markedly in both groups with stress. With 20 min of immobilization stress, epinephrine and norepinephrine concentrations increased more in pendrin-null than in wild-type mice, although stress produced a similar increase in blood pressure in both groups. We conclude that pendrin is expressed in the adrenal medulla, where it blunts stress-induced catecholamine release. äPendrin localizes to the adrenal medulla and modulates catecholamine r(epmc).pdf DeepDyve Pubget Overpricing