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10.1152/ajprenal.00247.2015 http://scihub22266oqcxt.onion/10.1152/ajprenal.00247.2015 C4572395!4572395 !26202224     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26202224 &cmd=llinks): Failed to open stream: HTTP request failed! 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Renin expression in developing zebrafish is associated with angiogenesis and requires the Notch pathway and endothelium |pdf=|usr=}}{{26202224 }} gab.com Text Renin expression in developing zebrafish is associated with angiogenesis and requires the Notch pathway and endothelium JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26202224 #FOAvip Although renin is a critical regulatory enzyme of the cardiovascular system, its roles in organogenesis and the establishment of cardiovascular homeostasis remain unclear. Mammalian renin-expressing cells are widespread in embryonic kidneys but are highly restricted, specialized endocrine cells in adults. With a functional pronephros, embryonic zebrafish are ideal for delineating the developmental functions of renin-expressing cells and the mechanisms governing renin transcription. Larval zebrafish renin expression originates in the mural cells of the juxtaglomerular anterior mesenteric artery and subsequently at extrarenal sites. The role of renin was determined by assessing responses to renin-angiotensin system blockade, salinity variation, and renal perfusion ablation. Renin expression did not respond to renal flow ablation but was modulated by inhibition of angiotensin-converting enzyme and altered salinity. Our data in larval fish are consistent with conservation of renin's physiological functions. Using transgenic renin reporter fish, with mindbomb and cloche mutants, we show that Notch signaling and the endothelium are essential for developmental renin expression. After inhibition of angiogenesis, renin-expressing cells precede angiogenic sprouts. Arising from separate lineages, but relying on mutual interplay with endothelial cells, renin-expressing cells are among the earliest mural cells observed in larval fish, performing both endocrine and paracrine functions. Twit Text FOAVip Renin expression in developing zebrafish is associated with angiogenesis and requires the Notch pathway and endothelium ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26202224 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26202224 #FOAvip English Wikipedia <ref>{{Cite pmid|26202224 }}</ref> Renin expression in developing zebrafish is associated with angiogenesis and requires the Notch pathway and endothelium #MMPMID26202224 Rider SA ; Mullins LJ ; Verdon RF ; MacRae CA ; Mullins JJ Am J Physiol Renal Physiol 2015[Sep]; 309 (6 ): F531-9 PMID26202224 show ga Although renin is a critical regulatory enzyme of the cardiovascular system, its roles in organogenesis and the establishment of cardiovascular homeostasis remain unclear. Mammalian renin-expressing cells are widespread in embryonic kidneys but are highly restricted, specialized endocrine cells in adults. With a functional pronephros, embryonic zebrafish are ideal for delineating the developmental functions of renin-expressing cells and the mechanisms governing renin transcription. Larval zebrafish renin expression originates in the mural cells of the juxtaglomerular anterior mesenteric artery and subsequently at extrarenal sites. The role of renin was determined by assessing responses to renin-angiotensin system blockade, salinity variation, and renal perfusion ablation. Renin expression did not respond to renal flow ablation but was modulated by inhibition of angiotensin-converting enzyme and altered salinity. Our data in larval fish are consistent with conservation of renin's physiological functions. Using transgenic renin reporter fish, with mindbomb and cloche mutants, we show that Notch signaling and the endothelium are essential for developmental renin expression. After inhibition of angiogenesis, renin-expressing cells precede angiogenic sprouts. Arising from separate lineages, but relying on mutual interplay with endothelial cells, renin-expressing cells are among the earliest mural cells observed in larval fish, performing both endocrine and paracrine functions. |Animals [MESH] |Endothelium, Vascular/*metabolism [MESH] |Hemodynamics/physiology [MESH] |Larva [MESH] |Neovascularization, Physiologic/genetics/*physiology [MESH] |Receptors, Notch/genetics/*metabolism [MESH] |Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors [MESH] |Regional Blood Flow/physiology [MESH] |Renin/*biosynthesis/genetics [MESH] |Signal Transduction/genetics/physiology [MESH]Renin expression in developing zebrafish is associated with angiogenes(epmc).pdf DeepDyve Pubget Overpricing