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10.3748/wjg.v10.i22.3318

http://scihub22266oqcxt.onion/10.3748/wjg.v10.i22.3318
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C4572303!4572303!15484308
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suck abstract from ncbi


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pmid15484308      World+J+Gastroenterol 2004 ; 10 (22): 3318-21
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  • Opisthorchiasis-associated biliary stones: Light and scanning electron microscopic study #MMPMID15484308
  • Sripa B; Kanla P; Sinawat P; Haswell-Elkins MR
  • World J Gastroenterol 2004[Nov]; 10 (22): 3318-21 PMID15484308show ga
  • AIM: Biliary stones are frequently encountered in areas endemic for opisthorchiasis in Thailand. The present study was to describe the prevalence and pathogenesis of these stones.METHODS: Gallstones and/or common bile duct stones and bile specimens from 113 consecutive cholecystectomies were included. Bile samples, including sludge and/or microcalculi, were examined for Opisthorchisviverrini eggs, calcium and bilirubin. The stones were also processed for scanning electron microscopic (SEM) study.RESULTS: Of the 113 cases, 82 had pigment stones, while one had cholesterol stones. The other 30 cases had no stones. Most of the stone cases (76%, 63/83) had multiple stones, while the remainder had a single stone. Stones were more frequently observed in females. Bile examination was positive for O.viverrini eggs in 50% of the cases studied. Aggregates of calcium bilirubinate precipitates were observed in all cases with sludge. Deposition of calcium bilirubinate on the eggshell was visualized by special staining. A SEM study demonstrated the presence of the parasite eggs in the stones. Numerous crystals, morphologically consistent with calcium derivatives and cholesterol precipitates, were seen.CONCLUSION: Northeast Thailand has a high prevalence of pigment stones, as observed at the cholecystectomy, and liver fluke infestation seems involved in the pathogenesis of stone formation.
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