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10.3748/wjg.v10.i18.2740 http://scihub22266oqcxt.onion/10.3748/wjg.v10.i18.2740 C4572205!4572205!15309731     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Gastroenterol 2004 ; 10 (18): 2740-3 Nephropedia Template TP {{tp|p=15309731|t=2004. Clinical significance of serum IGF-I, IGF-II and IGFBP-3 in liver cirrhosis |pdf=|usr=}}{{15309731}} gab.com Text Clinical significance of serum IGF-I, IGF-II and IGFBP-3 in liver cirrhosis JO: World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=15309731 #FOAvip AIM: To investigate the relationship between insulin-like growth factor-I, -II (IGF-I and IGF-II), IGF-binding protein 3 (IGFBP-3) and Child-Pugh score in patients with liver cirrhosis, and to search for potential clinical markers of liver function.METHODS: Forty-four patients with advanced liver cirrhosis of viral origin were divided into 3 groups according to severity of cirrhosis (Child-Pugh score) and 38 healthy subjects served as controls. Serum levels of IGF-I, IGF-II and IGFBP-3 were measured by immunoradiometric assay.RESULTS: Serum IGF-I, IGF-II and IGFBP-3 levels were significantly lower in patients with cirrhosis than in controls, and serum concentrations of IGF-I, IGF-II and IGFBP-3 were associated with the severity of liver dysfunction, and dropped sharply during the progression of liver failure. Among these 3 parameters, serum IGF-II was the most sensitive and effective indicator for liver dysfunction. Concentrations of IGF-I < 30 ng/mL, IGF-II < 200 ng/mL and IGFBP-3 < 6 ng/mL implied a negative prognosis for patients with liver cirrhosis.CONCLUSION: Serum IGF-I, IGF-II and IGFBP-3 may provide a new dimension in the assessment of liver dysfunction. Combined detection of serum IGF-I, IGF-II and IGFBP-3 with Child-Pugh score is more effective in predicting prognosis than Child-Pugh score alone. Twit Text FOAVip Clinical significance of serum IGF-I, IGF-II and IGFBP-3 in liver cirrhosis ????World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=15309731 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15309731 #FOAvip English Wikipedia <ref>{{Cite pmid|15309731}}</ref> Clinical significance of serum IGF-I, IGF-II and IGFBP-3 in liver cirrhosis #MMPMID15309731 Wu YL; Ye J; Zhang S; Zhong J; Xi RP World J Gastroenterol 2004[Sep]; 10 (18): 2740-3 PMID15309731show ga AIM: To investigate the relationship between insulin-like growth factor-I, -II (IGF-I and IGF-II), IGF-binding protein 3 (IGFBP-3) and Child-Pugh score in patients with liver cirrhosis, and to search for potential clinical markers of liver function.METHODS: Forty-four patients with advanced liver cirrhosis of viral origin were divided into 3 groups according to severity of cirrhosis (Child-Pugh score) and 38 healthy subjects served as controls. Serum levels of IGF-I, IGF-II and IGFBP-3 were measured by immunoradiometric assay.RESULTS: Serum IGF-I, IGF-II and IGFBP-3 levels were significantly lower in patients with cirrhosis than in controls, and serum concentrations of IGF-I, IGF-II and IGFBP-3 were associated with the severity of liver dysfunction, and dropped sharply during the progression of liver failure. Among these 3 parameters, serum IGF-II was the most sensitive and effective indicator for liver dysfunction. Concentrations of IGF-I < 30 ng/mL, IGF-II < 200 ng/mL and IGFBP-3 < 6 ng/mL implied a negative prognosis for patients with liver cirrhosis.CONCLUSION: Serum IGF-I, IGF-II and IGFBP-3 may provide a new dimension in the assessment of liver dysfunction. Combined detection of serum IGF-I, IGF-II and IGFBP-3 with Child-Pugh score is more effective in predicting prognosis than Child-Pugh score alone. äClinical significance of serum IGF-I, IGF-II and IGFBP-3 in liver cirr(epmc).pdf DeepDyve Pubget Overpricing