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10.1074/jbc.M115.671222 http://scihub22266oqcxt.onion/10.1074/jbc.M115.671222 C4571980!4571980!26205818     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2015 ; 290 (36): 22287-97 Nephropedia Template TP {{tp|p=26205818|t=2015. Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells* |pdf=|usr=}}{{26205818}} gab.com Text Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26205818 #FOAvip Background: Fe(II)-dependent dioxygenases regulate epigenetic control, collagen maturation, and HIF degradation.Results: Iron chelation by fluoroquinolone antibiotics results in DNA and histone hypermethylation, suppression of collagen prolyl hydroxylation, and inhibition of HIF mRNA translation.Conclusion: Dioxygenase inhibition may explain renal toxicity and tendinopathy side effects of fluoroquinolones.Significance: This study suggests mechanisms for obscure fluoroquinolone-associated side effects and possible novel applications of these antibiotics as HIF antagonists. Twit Text FOAVip Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26205818 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26205818 #FOAvip English Wikipedia <ref>{{Cite pmid|26205818}}</ref> Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells* #MMPMID26205818 Badal S; Her YF; Maher LJ J Biol Chem 2015[Sep]; 290 (36): 22287-97 PMID26205818show ga Background: Fe(II)-dependent dioxygenases regulate epigenetic control, collagen maturation, and HIF degradation.Results: Iron chelation by fluoroquinolone antibiotics results in DNA and histone hypermethylation, suppression of collagen prolyl hydroxylation, and inhibition of HIF mRNA translation.Conclusion: Dioxygenase inhibition may explain renal toxicity and tendinopathy side effects of fluoroquinolones.Significance: This study suggests mechanisms for obscure fluoroquinolone-associated side effects and possible novel applications of these antibiotics as HIF antagonists. äNonantibiotic Effects of Fluoroquinolones in Mammalian Cells* (epmc).pdf DeepDyve Pubget Overpricing