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10.1074/jbc.M115.640094

http://scihub22266oqcxt.onion/10.1074/jbc.M115.640094
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suck abstract from ncbi


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pmid26198639      J+Biol+Chem 2015 ; 290 (36): 22174-83
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  • A Metabolic Shift toward Pentose Phosphate Pathway Is Necessary for Amyloid Fibril- and Phorbol 12-Myristate 13-Acetate-induced Neutrophil Extracellular Trap (NET) Formation* #MMPMID26198639
  • Azevedo EP; Rochael NC; Guimarães-Costa AB; de Souza-Vieira TS; Ganilho J; Saraiva EM; Palhano FL; Foguel D
  • J Biol Chem 2015[Sep]; 290 (36): 22174-83 PMID26198639show ga
  • Background: Neutrophil extracellular traps (NETs) are DNA meshes that snare and kill microorganisms, impeding their dissemination.Results: Glucose but not fructose supports NET formation through a metabolic shift toward pentose phosphate pathway (PPP).Conclusion: PPP impairment leads to decreased NET production.Significance: This study provides novel knowledge about the mechanisms of NET induction, opening new avenues of study and intervention.
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