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10.1074/jbc.M115.652222

http://scihub22266oqcxt.onion/10.1074/jbc.M115.652222
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C4571963!4571963!26183774
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suck abstract from ncbi


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pmid26183774      J+Biol+Chem 2015 ; 290 (36): 22127-42
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  • Fibroblast Growth Factor 9 Imparts Hierarchy and Vasoreactivity to the Microcirculation of Renal Tumors and Suppresses Metastases* #MMPMID26183774
  • Yin H; Frontini MJ; Arpino JM; Nong Z; O'Neil C; Xu Y; Balint B; Ward AD; Chakrabarti S; Ellis CG; Gros R; Pickering JG
  • J Biol Chem 2015[Sep]; 290 (36): 22127-42 PMID26183774show ga
  • Background: Tumor microvessels are non-hierarchical and regulate blood flow poorly.Results: Delivery of fibroblast growth factor 9 (FGF9) reconfigured the chaotic renal tumor vasculature into a fortified, hierarchical, and vasoreactive network by activating PDGFR?+-stromal cells. Tumor hypoxia and metastases declined.Conclusion: FGF9 can generate a vasoreactive tumor microcirculation.Significance: This advanced state of microvascular differentiation could favorably impact tumor behavior.
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