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10.1074/jbc.M115.652222 http://scihub22266oqcxt.onion/10.1074/jbc.M115.652222 C4571963!4571963 !26183774     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26183774 &cmd=llinks): Failed to open stream: HTTP request failed! 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Fibroblast Growth Factor 9 Imparts Hierarchy and Vasoreactivity to the Microcirculation of Renal Tumors and Suppresses Metastases |pdf=|usr=}}{{26183774 }} gab.com Text Fibroblast Growth Factor 9 Imparts Hierarchy and Vasoreactivity to the Microcirculation of Renal Tumors and Suppresses Metastases JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26183774 #FOAvip Tumor vessel normalization has been proposed as a therapeutic paradigm. However, normal microvessels are hierarchical and vasoreactive with single file transit of red blood cells through capillaries. Such a network has not been identified in malignant tumors. We tested whether the chaotic tumor microcirculation could be reconfigured by the mesenchyme-selective growth factor, FGF9. Delivery of FGF9 to renal tumors in mice yielded microvessels that were covered by pericytes, smooth muscle cells, and a collagen-fortified basement membrane. This was associated with reduced pulmonary metastases. Intravital microvascular imaging revealed a haphazard web of channels in control tumors but a network of arterioles, bona fide capillaries, and venules in FGF9-expressing tumors. Moreover, whereas vasoreactivity was absent in control tumors, arterioles in FGF9-expressing tumors could constrict and dilate in response to adrenergic and nitric oxide releasing agents, respectively. These changes were accompanied by reduced hypoxia in the tumor core and reduced expression of the angiogenic factor VEGF-A. FGF9 was found to selectively amplify a population of PDGFR?-positive stromal cells in the tumor and blocking PDGFR? prevented microvascular differentiation by FGF9 and also worsened metastases. We conclude that harnessing local mesenchymal stromal cells with FGF9 can differentiate the tumor microvasculature to an extent not observed previously. Twit Text FOAVip Fibroblast Growth Factor 9 Imparts Hierarchy and Vasoreactivity to the Microcirculation of Renal Tumors and Suppresses Metastases ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26183774 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26183774 #FOAvip English Wikipedia <ref>{{Cite pmid|26183774 }}</ref> Fibroblast Growth Factor 9 Imparts Hierarchy and Vasoreactivity to the Microcirculation of Renal Tumors and Suppresses Metastases #MMPMID26183774 Yin H ; Frontini MJ ; Arpino JM ; Nong Z ; O'Neil C ; Xu Y ; Balint B ; Ward AD ; Chakrabarti S ; Ellis CG ; Gros R ; Pickering JG J Biol Chem 2015[Sep]; 290 (36 ): 22127-42 PMID26183774 show ga Tumor vessel normalization has been proposed as a therapeutic paradigm. However, normal microvessels are hierarchical and vasoreactive with single file transit of red blood cells through capillaries. Such a network has not been identified in malignant tumors. We tested whether the chaotic tumor microcirculation could be reconfigured by the mesenchyme-selective growth factor, FGF9. Delivery of FGF9 to renal tumors in mice yielded microvessels that were covered by pericytes, smooth muscle cells, and a collagen-fortified basement membrane. This was associated with reduced pulmonary metastases. Intravital microvascular imaging revealed a haphazard web of channels in control tumors but a network of arterioles, bona fide capillaries, and venules in FGF9-expressing tumors. Moreover, whereas vasoreactivity was absent in control tumors, arterioles in FGF9-expressing tumors could constrict and dilate in response to adrenergic and nitric oxide releasing agents, respectively. These changes were accompanied by reduced hypoxia in the tumor core and reduced expression of the angiogenic factor VEGF-A. FGF9 was found to selectively amplify a population of PDGFR?-positive stromal cells in the tumor and blocking PDGFR? prevented microvascular differentiation by FGF9 and also worsened metastases. We conclude that harnessing local mesenchymal stromal cells with FGF9 can differentiate the tumor microvasculature to an extent not observed previously. |*Microcirculation [MESH] |Animals [MESH] |Cell Line [MESH] |Cell Line, Tumor [MESH] |Cells, Cultured [MESH] |Female [MESH] |Fibroblast Growth Factor 9/*genetics/metabolism [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Immunoblotting [MESH] |Kidney Neoplasms/*blood supply/*genetics/pathology [MESH] |Lung Neoplasms/genetics/metabolism/secondary [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |Receptor, Platelet-Derived Growth Factor beta/genetics/metabolism [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Transgenes/genetics [MESH]Fibroblast Growth Factor 9 Imparts Hierarchy and Vasoreactivity to the(epmc).pdf DeepDyve Pubget Overpricing