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10.1074/jbc.M115.671339

http://scihub22266oqcxt.onion/10.1074/jbc.M115.671339
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C4571961!4571961!26195629
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suck abstract from ncbi


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pmid26195629      J+Biol+Chem 2015 ; 290 (36): 22101-10
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  • A Role for Autoinhibition in Preventing Dimerization of the Transcription Factor ETS1* #MMPMID26195629
  • Samorodnitsky D; Szyjka C; Koudelka GB
  • J Biol Chem 2015[Sep]; 290 (36): 22101-10 PMID26195629show ga
  • Background: The transcription factor ETS1 controls its DNA binding activity through an autoinhibitory module.Results: The relationship between specific and nonspecific DNA binding, homodimer formation, and autoinhibition was explored.Conclusion: ETS1 transiently forms dimers as a consequence of interacting with any DNA sequence.Significance: Relief of autoinhibition by nonspecific DNA interaction leading to subsequent ETS1 dimerization may represent a conserved element of DNA recognition across the ETS family.
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