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10.1074/jbc.M115.657924

http://scihub22266oqcxt.onion/10.1074/jbc.M115.657924
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C4571888!4571888!26126828
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suck abstract from ncbi


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pmid26126828      J+Biol+Chem 2015 ; 290 (35): 21652-62
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  • Distinct Therapeutic Mechanisms of Tau Antibodies: PROMOTING MICROGLIAL CLEARANCE VERSUS BLOCKING NEURONAL UPTAKE* #MMPMID26126828
  • Funk KE; Mirbaha H; Jiang H; Holtzman DM; Diamond MI
  • J Biol Chem 2015[Aug]; 290 (35): 21652-62 PMID26126828show ga
  • Background: Vaccination against Tau reduces pathology in vivo; however, the mechanism of action remains unclear.Results: Antibodies promote uptake of Tau fibrils in microglia or block uptake in neurons in a size- and epitope-dependent manner.Conclusion: Antibodies have multiple potential mechanisms.Significance: Establishing specific mechanisms of antibody activity may help in design and optimization of more effective agents.
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