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2014 ; 48
(4
): 262-71
Nephropedia Template TP
gab.com Text
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English Wikipedia
Tc-99m Hydroxymethylene Diphosphonate (HMDP) Renal Uptake as a Surrogate Marker
of Postoperative Impairment of the Glomerular Filtration Rate in Renal Tumor
Patients Following Nephron-Sparing Surgery
#MMPMID26396630
Choi H
; Lee WW
; So Y
; Ha S
; Byun SS
; Kim SE
Nucl Med Mol Imaging
2014[Dec]; 48
(4
): 262-71
PMID26396630
show ga
PURPOSE: We investigated Tc-99m hydroxymethylene diphosphonate (HMDP)
scintigraphy findings in renal tumor patients from the perspective of
postoperative renal dysfunction following nephron-sparing surgery (NSS). METHODS:
Forty-three renal tumor patients (M:F = 28:15, age 53.9?±?12.5 years) who had
undergone Tc-99m HMDP scintigraphy after NSS were enrolled. The patients were
divided into HMDP(+) or HMDP(-) groups by visual assessment, and the asymmetric
index (ASI) was calculated using a region-of-interest analysis. In 16 patients,
the total and split glomerular filtration rate (GFR) was assessed using Tc-99m
diethylenetriaminepentaacetic acid (DTPA) scintigraphy at baseline and at 3 and 6
months post-NSS. RESULTS: High Tc-99m HMDP uptake was observed in the operated
kidneys, but this did not persist later than 7 days post-NSS. Split GFR of the
operated kidneys at baseline (58.5?±?9.3 ml/min) was significantly reduced at
6 months post-NSS (40.1?±?5.9 ml/min, p?0.001) in only those who showed intense
uptake of Tc-99m HMDP. Declines in both total GFR (p?=?0.010 and p?=?0.002 for 3
and 6 months, respectively) and split GFR of the operated kidneys (p?0.001 and
p?0.001 for 3 and 6 months, respectively) were clearly evidenced at 3 and
6 months post-NSS only in patients with high Tc-99m HMDP in the operated kidneys.
The ASI was negatively correlated with %change in the split GFR of these operated
kidneys at 6 months post-NSS (rho =-0.578, p?=?0.0304). CONCLUSIONS: Tc-99m HMDP
uptake within 1 week following NSS is a surrogate marker of GFR impairment over
6 months post-NSS.