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10.1038/srep14269 http://scihub22266oqcxt.onion/10.1038/srep14269 C4571616!4571616!26373678     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26373678|t=2015. Nanobody-targeted E3-ubiquitin ligase complex degrades nuclear proteins |pdf=|usr=}}{{26373678}} gab.com Text Nanobody-targeted E3-ubiquitin ligase complex degrades nuclear proteins JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26373678 #FOAvip Targeted protein degradation is a powerful tool in determining the function of specific proteins or protein complexes. We fused nanobodies to SPOP, an adaptor protein of the Cullin-RING E3 ubiquitin ligase complex, resulting in rapid ubiquitination and subsequent proteasome-dependent degradation of specific nuclear proteins in mammalian cells and zebrafish embryos. This approach is easily modifiable, as substrate specificity is conferred by an antibody domain that can be adapted to target virtually any protein. Twit Text FOAVip Nanobody-targeted E3-ubiquitin ligase complex degrades nuclear proteins ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26373678 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26373678 #FOAvip English Wikipedia <ref>{{Cite pmid|26373678}}</ref> Nanobody-targeted E3-ubiquitin ligase complex degrades nuclear proteins #MMPMID26373678 Ju Shin Y; Kyun Park S; Jung Jung Y; Na Kim Y; Sung Kim K; Kyu Park O; Kwon SH; Ho Jeon S; Trinh LA; Fraser SE; Kee Y; Joon Hwang B Sci Rep 2015[]; 5 (ä): ä PMID26373678show ga Targeted protein degradation is a powerful tool in determining the function of specific proteins or protein complexes. We fused nanobodies to SPOP, an adaptor protein of the Cullin-RING E3 ubiquitin ligase complex, resulting in rapid ubiquitination and subsequent proteasome-dependent degradation of specific nuclear proteins in mammalian cells and zebrafish embryos. This approach is easily modifiable, as substrate specificity is conferred by an antibody domain that can be adapted to target virtually any protein. äNanobody-targeted E3-ubiquitin ligase complex degrades nuclear protein(epmc).pdf DeepDyve Pubget Overpricing