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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Mol+Biol+Cell 2015 ; 26 (16): 2873-84 Nephropedia Template TP
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Ire1-mediated decay in mammalian cells relies on mRNA sequence, structure, and translational status #MMPMID26108623
Moore K; Hollien J
Mol Biol Cell 2015[Aug]; 26 (16): 2873-84 PMID26108623show ga
Endoplasmic reticulum (ER) stress induces the degradation of mRNAs by Ire1. In mammalian cells, this process depends on specific stem-loop structures in the target mRNAs and on Perk, a second sensor of ER stress. Perk appears to be required to translationally attenuate the stem-loop regions of target mRNAs.