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10.1038/aps.2014.118 http://scihub22266oqcxt.onion/10.1038/aps.2014.118 C4571317!4571317!25500873     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Pharmacol+Sin 2015 ; 36 (1): 113-8 Nephropedia Template TP {{tp|p=25500873|t=2015. Bridging cell surface receptor with nuclear receptors in control of bile acid homeostasis |pdf=|usr=}}{{25500873}} gab.com Text Bridging cell surface receptor with nuclear receptors in control of bile acid homeostasis JO: Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=25500873 #FOAvip Bile acids (BAs) are traditionally considered as ?physiological detergents? for emulsifying hydrophobic lipids and vitamins due to their amphipathic nature. But accumulating clinical and experimental evidence shows an association between disrupted BA homeostasis and various liver disease conditions including hepatitis infection, diabetes and cancer. Consequently, BA homeostasis regulation has become a field of heavy interest and investigation. After identification of the Farnesoid X Receptor (FXR) as an endogenous receptor for BAs, several nuclear receptors (SHP, HNF4?, and LRH-1) were also found to be important in regulation of BA homeostasis. Some post-translational modifications of these nuclear receptors have been demonstrated, but their physiological significance is still elusive. Gut secrets FGF15/19 that can activate hepatic FGFR4 and its downstream signaling cascade, leading to repressed hepatic BA biosynthesis. However, the link between the activated kinases and these nuclear receptors is not fully elucidated. Here, we review the recent literature on signal crosstalk in BA homeostasis. Twit Text FOAVip Bridging cell surface receptor with nuclear receptors in control of bile acid homeostasis ????Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=25500873 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25500873 #FOAvip English Wikipedia <ref>{{Cite pmid|25500873}}</ref> Bridging cell surface receptor with nuclear receptors in control of bile acid homeostasis #MMPMID25500873 Li S; Ni A; Feng Gs Acta Pharmacol Sin 2015[Jan]; 36 (1): 113-8 PMID25500873show ga Bile acids (BAs) are traditionally considered as ?physiological detergents? for emulsifying hydrophobic lipids and vitamins due to their amphipathic nature. But accumulating clinical and experimental evidence shows an association between disrupted BA homeostasis and various liver disease conditions including hepatitis infection, diabetes and cancer. Consequently, BA homeostasis regulation has become a field of heavy interest and investigation. After identification of the Farnesoid X Receptor (FXR) as an endogenous receptor for BAs, several nuclear receptors (SHP, HNF4?, and LRH-1) were also found to be important in regulation of BA homeostasis. Some post-translational modifications of these nuclear receptors have been demonstrated, but their physiological significance is still elusive. Gut secrets FGF15/19 that can activate hepatic FGFR4 and its downstream signaling cascade, leading to repressed hepatic BA biosynthesis. However, the link between the activated kinases and these nuclear receptors is not fully elucidated. Here, we review the recent literature on signal crosstalk in BA homeostasis. äBridging cell surface receptor with nuclear receptors in control of bi(epmc).pdf DeepDyve Pubget Overpricing