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10.1021/acscentsci.5b00164 http://scihub22266oqcxt.onion/10.1021/acscentsci.5b00164 C4571170!4571170!26405690     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Cent+Sci 2015 ; 1 (4): 181-90 Nephropedia Template TP {{tp|p=26405690|t=2015. Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1 |pdf=|usr=}}{{26405690}} gab.com Text Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1 JO: ACS Cent Sci http://www.kidney.de/pget.php?&tw=1&pmid=26405690 #FOAvip Pancreatic-type ribonucleases are secretory enzymes that catalyze the cleavage of RNA. Recent efforts have endowed the homologues from cow (RNase A) and human (RNase 1) with toxicity for cancer cells, leading to a clinical trial. The basis for the selective toxicity of ribonuclease variants for cancerous versus noncancerous cells has, however, been unclear. A screen for RNase A ligands in an array of mammalian cell-surface glycans revealed strong affinity for a hexasaccharide, Globo H, that is a tumor-associated antigen and the basis for a vaccine in clinical trials. The affinity of RNase A and RNase 1 for immobilized Globo H is in the low micromolar?high nanomolar range. Moreover, reducing the display of Globo H on the surface of human breast adenocarcinoma cells with a small-molecule inhibitor of biosynthesis or a monoclonal antibody antagonist decreases the toxicity of an RNase 1 variant. Finally, heteronuclear single quantum coherence (HSQC) NMR spectroscopy showed that RNase 1 interacts with Globo H by using residues that are distal from the enzymic active site. The discovery that a systemic human ribonuclease binds to a moiety displayed on human cancer cells links two clinical paradigms and suggests a mechanism for innate resistance to cancer. Twit Text FOAVip Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1 ????ACS Cent Sci http://www.kidney.de/pget.php?&tw=1&pmid=26405690 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26405690 #FOAvip English Wikipedia <ref>{{Cite pmid|26405690}}</ref> Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1 #MMPMID26405690 Eller C; Chao TY; Singarapu KK; Ouerfelli O; Yang G; Markley JL; Danishefsky SJ; Raines RT ACS Cent Sci 2015[Jul]; 1 (4): 181-90 PMID26405690show ga Pancreatic-type ribonucleases are secretory enzymes that catalyze the cleavage of RNA. Recent efforts have endowed the homologues from cow (RNase A) and human (RNase 1) with toxicity for cancer cells, leading to a clinical trial. The basis for the selective toxicity of ribonuclease variants for cancerous versus noncancerous cells has, however, been unclear. A screen for RNase A ligands in an array of mammalian cell-surface glycans revealed strong affinity for a hexasaccharide, Globo H, that is a tumor-associated antigen and the basis for a vaccine in clinical trials. The affinity of RNase A and RNase 1 for immobilized Globo H is in the low micromolar?high nanomolar range. Moreover, reducing the display of Globo H on the surface of human breast adenocarcinoma cells with a small-molecule inhibitor of biosynthesis or a monoclonal antibody antagonist decreases the toxicity of an RNase 1 variant. Finally, heteronuclear single quantum coherence (HSQC) NMR spectroscopy showed that RNase 1 interacts with Globo H by using residues that are distal from the enzymic active site. The discovery that a systemic human ribonuclease binds to a moiety displayed on human cancer cells links two clinical paradigms and suggests a mechanism for innate resistance to cancer. äHuman Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonu(epmc).pdf DeepDyve Pubget Overpricing