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10.1016/j.cell.2015.08.025 http://scihub22266oqcxt.onion/10.1016/j.cell.2015.08.025 C4570563!4570563!26359987     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2015 ; 162 (6): 1338-52 Nephropedia Template TP {{tp|p=26359987|t=2015. Melatonin Contributes To The Seasonality Of Multiple Sclerosis Relapses |pdf=|usr=}}{{26359987}} gab.com Text Melatonin Contributes To The Seasonality Of Multiple Sclerosis Relapses JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=26359987 #FOAvip Seasonal changes in disease activity have been observed in multiple sclerosis, an autoimmune disorder that affects the central nervous system. These epidemiological observations suggest that environmental factors influence the disease course. Here we report that melatonin levels, whose production is modulated by seasonal variations in night length, negatively correlate with multiple sclerosis activity in humans. Treatment with melatonin ameliorates disease in an experimental model of multiple sclerosis and directly interferes with the differentiation of human and mouse T cells. Melatonin induces the expression of the repressor transcription factor Nfil3, blocking the differentiation of pathogenic Th17 cells as well as boosts the generation of protective Tr1 cells via Erk1/2 and the transactivation of the IL-10 promoter by ROR-?. These results suggest that melatonin is another example of how environmental-driven cues can impact on T cell differentiation and have implications for autoimmune disorders such as multiple sclerosis. Twit Text FOAVip Melatonin Contributes To The Seasonality Of Multiple Sclerosis Relapses ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=26359987 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26359987 #FOAvip English Wikipedia <ref>{{Cite pmid|26359987}}</ref> Melatonin Contributes To The Seasonality Of Multiple Sclerosis Relapses #MMPMID26359987 Farez MF; Mascanfroni ID; Méndez-Huergo SP; Yeste A; Murugaiyan G; Garo LP; Balbuena Aguirre ME; Patel B; Ysrraelit MC; Zhu C; Kuchroo VK; Rabinovich GA; Quintana FJ; Correale J Cell 2015[Sep]; 162 (6): 1338-52 PMID26359987show ga Seasonal changes in disease activity have been observed in multiple sclerosis, an autoimmune disorder that affects the central nervous system. These epidemiological observations suggest that environmental factors influence the disease course. Here we report that melatonin levels, whose production is modulated by seasonal variations in night length, negatively correlate with multiple sclerosis activity in humans. Treatment with melatonin ameliorates disease in an experimental model of multiple sclerosis and directly interferes with the differentiation of human and mouse T cells. Melatonin induces the expression of the repressor transcription factor Nfil3, blocking the differentiation of pathogenic Th17 cells as well as boosts the generation of protective Tr1 cells via Erk1/2 and the transactivation of the IL-10 promoter by ROR-?. These results suggest that melatonin is another example of how environmental-driven cues can impact on T cell differentiation and have implications for autoimmune disorders such as multiple sclerosis. äMelatonin Contributes To The Seasonality Of Multiple Sclerosis Relapse(epmc).pdf DeepDyve Pubget Overpricing