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10.1038/srep14046 http://scihub22266oqcxt.onion/10.1038/srep14046 C4570190!4570190 !26370586     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26370586 &cmd=llinks): Failed to open stream: HTTP request failed! 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Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents |pdf=|usr=}}{{26370586 }} gab.com Text Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26370586 #FOAvip Regulatory T cells (Treg) play a critical role to control immune responses and to prevent autoimmunity, thus selective increase of Treg cells in vivo has broad therapeutic implications for autoimmune and inflammatory diseases. Licorice is a well-known herbal medicine used worldwide for over thousands of years, and accumulating evidence has shown its immunomodulatory potential. However, it is not clear whether licorice could regulate the induction and function of Treg cells. Here we found licorice extract could promote Treg cell induction, and then we used a rational approach to isolate its functional fractions and constituents. The results showed that two constituents, isoliquiritigenin and naringenin, promoted Treg cell induction both in vitro and in vivo. The effective fractions and two constituents of licorice also enhanced immune suppression of Treg cells, and they further reduced severity of DSS-induced colitis in mice. This study suggested that promotion of regulatory T cell induction could be an underlying mechanism of the historically and widely used herbal medicine licorice, providing its two effective molecules against autoimmune and inflammatory diseases. Twit Text FOAVip Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26370586 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26370586 #FOAvip English Wikipedia <ref>{{Cite pmid|26370586 }}</ref> Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents #MMPMID26370586 Guo A ; He D ; Xu HB ; Geng CA ; Zhao J Sci Rep 2015[Sep]; 5 (ä): 14046 PMID26370586 show ga Regulatory T cells (Treg) play a critical role to control immune responses and to prevent autoimmunity, thus selective increase of Treg cells in vivo has broad therapeutic implications for autoimmune and inflammatory diseases. Licorice is a well-known herbal medicine used worldwide for over thousands of years, and accumulating evidence has shown its immunomodulatory potential. However, it is not clear whether licorice could regulate the induction and function of Treg cells. Here we found licorice extract could promote Treg cell induction, and then we used a rational approach to isolate its functional fractions and constituents. The results showed that two constituents, isoliquiritigenin and naringenin, promoted Treg cell induction both in vitro and in vivo. The effective fractions and two constituents of licorice also enhanced immune suppression of Treg cells, and they further reduced severity of DSS-induced colitis in mice. This study suggested that promotion of regulatory T cell induction could be an underlying mechanism of the historically and widely used herbal medicine licorice, providing its two effective molecules against autoimmune and inflammatory diseases. |*Herbal Medicine [MESH] |Animals [MESH] |Cell Differentiation/drug effects/immunology [MESH] |Chalcones/pharmacology [MESH] |Colitis/chemically induced/drug therapy/immunology/pathology [MESH] |Disease Models, Animal [MESH] |Flavanones/pharmacology [MESH] |Glycyrrhiza/*chemistry [MESH] |Immunologic Factors/*pharmacology [MESH] |Lymphocyte Count [MESH] |Mice [MESH] |Plant Extracts/chemistry/*pharmacology [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |Receptors, Antigen, T-Cell/metabolism [MESH] |Receptors, Aryl Hydrocarbon/metabolism [MESH] |Signal Transduction/drug effects [MESH] |T-Lymphocytes, Regulatory/cytology/*drug effects/*immunology/metabolism [MESH]Promotion of regulatory T cell induction by immunomodulatory herbal me(epmc).pdf DeepDyve Pubget Overpricing