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10.1021/acsmedchemlett.5b00228 http://scihub22266oqcxt.onion/10.1021/acsmedchemlett.5b00228 C4569881!4569881!26396689     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26396689.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ACS+Med+Chem+Lett 2015 ; 6 (9): 1010-4 Nephropedia Template TP {{tp|p=26396689|t=2015. Novel 2-Carbonylbenzo b thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway |pdf=|usr=}}{{26396689}} gab.com Text Novel 2-Carbonylbenzo b thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=26396689 #FOAvip Signal transducer and activator of transcription 3 (STAT3) is considered to be an attractive therapeutic target for cancer therapy. In this study, a series of 2-carbonylbenzo[b]thiophene 1,1-dioxide derivatives (CBT) were designed to inhibit the STAT3 SH2 domain phosphorylation site Try 705. We demonstrated that incorporation of basic flexible groups through amide bond linkage to benzo[b]thiophene 1,1-dioxide (BTP) achieved compounds with higher antiproliferative potency than BTP itself. The most potent compound 6o, as indicated from luciferase reporter gene assay, inhibited the STAT3 pathway by decreasing the phosphorylation level of STAT3 Tyr705, while the phosphorylation level of other upstream tyrosine kinases in this pathway was not significantly inhibited. Compound 6o was also shown to trigger ROS generation and accumulation, thus consequently attributed partially to the observed cell apoptosis. This study provided important structural information for the development of inhibitors targeting the STAT3 pathway. Twit Text FOAVip Novel 2-Carbonylbenzo b thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=26396689 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26396689 #FOAvip English Wikipedia <ref>{{Cite pmid|26396689}}</ref> Novel 2-Carbonylbenzo b thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway #MMPMID26396689 Ji P; Xu X; Ma S; Fan J; Zhou Q; Mao X; Qiao C ACS Med Chem Lett 2015[Sep]; 6 (9): 1010-4 PMID26396689show ga Signal transducer and activator of transcription 3 (STAT3) is considered to be an attractive therapeutic target for cancer therapy. In this study, a series of 2-carbonylbenzo[b]thiophene 1,1-dioxide derivatives (CBT) were designed to inhibit the STAT3 SH2 domain phosphorylation site Try 705. We demonstrated that incorporation of basic flexible groups through amide bond linkage to benzo[b]thiophene 1,1-dioxide (BTP) achieved compounds with higher antiproliferative potency than BTP itself. The most potent compound 6o, as indicated from luciferase reporter gene assay, inhibited the STAT3 pathway by decreasing the phosphorylation level of STAT3 Tyr705, while the phosphorylation level of other upstream tyrosine kinases in this pathway was not significantly inhibited. Compound 6o was also shown to trigger ROS generation and accumulation, thus consequently attributed partially to the observed cell apoptosis. This study provided important structural information for the development of inhibitors targeting the STAT3 pathway. äNovel 2-Carbonylbenzo b thiophene 1,1-Dioxide Derivatives as Potent In(epmc).pdf DeepDyve Pubget Overpricing