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10.1038/ncomms9207 http://scihub22266oqcxt.onion/10.1038/ncomms9207 C4569847!4569847 !26360614     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26360614 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2015 ; 6 (ä): 8207 Nephropedia Template TP {{tp|p=26360614 |t=2015. Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development |pdf=|usr=}}{{26360614 }} gab.com Text Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26360614 #FOAvip Transcriptional program that drives human preimplantation development is largely unknown. Here, by using single-cell RNA sequencing of 348 oocytes, zygotes and single blastomeres from 2- to 3-day-old embryos, we provide a detailed analysis of the human preimplantation transcriptome. By quantifying transcript far 5'-ends (TFEs), we include in our analysis transcripts that derive from alternative promoters. We show that 32 and 129 genes are transcribed during the transition from oocyte to four-cell stage and from four- to eight-cell stage, respectively. A number of identified transcripts originates from previously unannotated genes that include the PRD-like homeobox genes ARGFX, CPHX1, CPHX2, DPRX, DUXA, DUXB and LEUTX. Employing de novo promoter motif extraction on sequences surrounding TFEs, we identify significantly enriched gene regulatory motifs that often overlap with Alu elements. Our high-resolution analysis of the human transcriptome during preimplantation development may have important implications on future studies of human pluripotent stem cells and cell reprograming. Twit Text FOAVip Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26360614 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26360614 #FOAvip English Wikipedia <ref>{{Cite pmid|26360614 }}</ref> Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development #MMPMID26360614 Töhönen V ; Katayama S ; Vesterlund L ; Jouhilahti EM ; Sheikhi M ; Madissoon E ; Filippini-Cattaneo G ; Jaconi M ; Johnsson A ; Bürglin TR ; Linnarsson S ; Hovatta O ; Kere J Nat Commun 2015[Sep]; 6 (ä): 8207 PMID26360614 show ga Transcriptional program that drives human preimplantation development is largely unknown. Here, by using single-cell RNA sequencing of 348 oocytes, zygotes and single blastomeres from 2- to 3-day-old embryos, we provide a detailed analysis of the human preimplantation transcriptome. By quantifying transcript far 5'-ends (TFEs), we include in our analysis transcripts that derive from alternative promoters. We show that 32 and 129 genes are transcribed during the transition from oocyte to four-cell stage and from four- to eight-cell stage, respectively. A number of identified transcripts originates from previously unannotated genes that include the PRD-like homeobox genes ARGFX, CPHX1, CPHX2, DPRX, DUXA, DUXB and LEUTX. Employing de novo promoter motif extraction on sequences surrounding TFEs, we identify significantly enriched gene regulatory motifs that often overlap with Alu elements. Our high-resolution analysis of the human transcriptome during preimplantation development may have important implications on future studies of human pluripotent stem cells and cell reprograming. |*Gene Expression Regulation, Developmental [MESH] |5' Untranslated Regions [MESH] |Blastocyst/*metabolism [MESH] |Blastomeres/*metabolism [MESH] |Embryonic Development/*genetics [MESH] |Gene Expression Profiling [MESH] |HEK293 Cells [MESH] |Homeodomain Proteins/*genetics/metabolism [MESH] |Humans [MESH] |Oocytes/*metabolism [MESH] |RNA, Messenger/*metabolism [MESH] |Retroelements/*genetics [MESH] |Sequence Analysis, RNA [MESH] |Transcription Factors/*genetics/metabolism [MESH]Novel PRD-like homeodomain transcription factors and retrotransposon e(epmc).pdf DeepDyve Pubget Overpricing