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10.4251/wjgo.v7.i9.132 http://scihub22266oqcxt.onion/10.4251/wjgo.v7.i9.132 C4569590!4569590!26380056     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26380056&cmd=llinks): Failed to open stream: HTTP request failed! 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Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review |pdf=|usr=}}{{26380056}} gab.com Text Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review JO: World J Gastrointest Oncol http://www.kidney.de/pget.php?&tw=1&pmid=26380056 #FOAvip Adenosquamous carcinoma of the pancreas (ASCP) is a rare entity. Like adenocarcinoma of the pancreas, overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP. Molecular characterization revealed overexpression in MRP1 (80%), MGMT (79%), TOP2A (75), RRM1 (42%), TOPO1 (42%), PTEN (45%), CMET (40%), and C-KIT (10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient?s tumor. Further work should be pursued to better characterize this disease. Twit Text FOAVip Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review ????World J Gastrointest Oncol http://www.kidney.de/pget.php?&tw=1&pmid=26380056 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26380056 #FOAvip English Wikipedia <ref>{{Cite pmid|26380056}}</ref> Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review #MMPMID26380056 Borazanci E; Millis SZ; Korn R; Han H; Whatcott CJ; Gatalica Z; Barrett MT; Cridebring D; Von Hoff DD World J Gastrointest Oncol 2015[Sep]; 7 (9): 132-40 PMID26380056show ga Adenosquamous carcinoma of the pancreas (ASCP) is a rare entity. Like adenocarcinoma of the pancreas, overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP. Molecular characterization revealed overexpression in MRP1 (80%), MGMT (79%), TOP2A (75), RRM1 (42%), TOPO1 (42%), PTEN (45%), CMET (40%), and C-KIT (10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient?s tumor. Further work should be pursued to better characterize this disease. äAdenosquamous carcinoma of the pancreas: Molecular characterization of(epmc).pdf DeepDyve Pubget Overpricing