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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 World+J+Gastrointest+Oncol
2015 ; 7
(9
): 132-40
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Adenosquamous carcinoma of the pancreas: Molecular characterization of 23
patients along with a literature review
#MMPMID26380056
Borazanci E
; Millis SZ
; Korn R
; Han H
; Whatcott CJ
; Gatalica Z
; Barrett MT
; Cridebring D
; Von Hoff DD
World J Gastrointest Oncol
2015[Sep]; 7
(9
): 132-40
PMID26380056
show ga
Adenosquamous carcinoma of the pancreas (ASCP) is a rare entity. Like
adenocarcinoma of the pancreas, overall survival is poor. Characteristics of ASCP
include central tumor necrosis, along with osteoclasts and hypercalcemia. Various
theories exist as to why this histological subtype exists, as normal pancreas
tissue has no benign squamous epithelium. Due to the rarity of this disease,
limited molecular analysis has been performed, and those reports indicate unique
molecular features of ASCP. In this paper, we characterize 23 patients diagnosed
with ASCP through molecular profiling using immunohistochemistry staining,
fluorescent in situ hybridization, chromogenic in situ hybridization, and gene
sequencing, Additionally, we provide a comprehensive literature review of what is
known to date of ASCP. Molecular characterization revealed overexpression in MRP1
(80%), MGMT (79%), TOP2A (75), RRM1 (42%), TOPO1 (42%), PTEN (45%), CMET (40%),
and C-KIT (10%) among others. One hundred percent of samples tested were positive
for KRAS mutations. This analysis shows heretofore unsuspected leads to be
considered for treatments of this rare type of exocrine pancreas cancer.
Molecular profiling may be appropriate to provide maximum information regarding
the patient's tumor. Further work should be pursued to better characterize this
disease.