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Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 PLoS+One 2015 ; 10 (9): ä Nephropedia Template TP
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MUC1 Predicts Colorectal Cancer Metastasis: A Systematic Review and Meta-Analysis of Case Controlled Studies #MMPMID26367866
Zeng Y; Zhang Q; Zhang Y; Lu M; Liu Y; Zheng T; Feng S; Hao M; Shi H
PLoS One 2015[]; 10 (9): ä PMID26367866show ga
Objective: To evaluate the predicting value of MUC1 expression in lymph node and distant metastasis of colorectal cancer (CRC). Methods: Pubmed/ MEDLINE and EMBASE were searched to identify eligible studies that evaluated the correlation between MUC1 and CRC. A meta-analysis was conducted to evaluate the impact of MUC1 expression on CRC metastasis. Results: A total of 18 studies (n = 3271) met inclusion criteria and the mean Newcastle-Ottawa Scale (NOS) score was 6.3 with a range from 4 to 8. The pooled OR in the meta-analysis of 15 studies indicated that positive MUC1 expression correlated with more CRC node metastasis (OR = 2.32, 95% CI = 1.63?3.29). The data synthesis of 6 studies suggested that MUC1 expression predicted more possibility of CRC distant metastasis (OR = 2.22, 95% CI = 1.23?4.00). In addition, the combined OR of 7 studies showed that MUC1 expression indicated higher Duke?s stage (OR = 3.02, 95% CI = 2.11?4.33). No publication bias was found in the mate-analysis by Begg?s test or Egger?s test with the exception of the meta-analysis of MUC1 with CRC node metastasis (Begg?s test p = 0.729, Egger?s test p = 0.000). Conclusions: Despite of some modest bias, the pooled evidence suggested that MUC1 expression was significantly correlated with CRC metastasis.