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10.1371/journal.pone.0138049

http://scihub22266oqcxt.onion/10.1371/journal.pone.0138049
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suck abstract from ncbi


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pmid26367866
      PLoS+One 2015 ; 10 (9 ): e0138049
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  • MUC1 Predicts Colorectal Cancer Metastasis: A Systematic Review and Meta-Analysis of Case Controlled Studies #MMPMID26367866
  • Zeng Y ; Zhang Q ; Zhang Y ; Lu M ; Liu Y ; Zheng T ; Feng S ; Hao M ; Shi H
  • PLoS One 2015[]; 10 (9 ): e0138049 PMID26367866 show ga
  • OBJECTIVE: To evaluate the predicting value of MUC1 expression in lymph node and distant metastasis of colorectal cancer (CRC). METHODS: Pubmed/ MEDLINE and EMBASE were searched to identify eligible studies that evaluated the correlation between MUC1 and CRC. A meta-analysis was conducted to evaluate the impact of MUC1 expression on CRC metastasis. RESULTS: A total of 18 studies (n = 3271) met inclusion criteria and the mean Newcastle-Ottawa Scale (NOS) score was 6.3 with a range from 4 to 8. The pooled OR in the meta-analysis of 15 studies indicated that positive MUC1 expression correlated with more CRC node metastasis (OR = 2.32, 95% CI = 1.63-3.29). The data synthesis of 6 studies suggested that MUC1 expression predicted more possibility of CRC distant metastasis (OR = 2.22, 95% CI = 1.23-4.00). In addition, the combined OR of 7 studies showed that MUC1 expression indicated higher Duke's stage (OR = 3.02, 95% CI = 2.11-4.33). No publication bias was found in the mate-analysis by Begg's test or Egger's test with the exception of the meta-analysis of MUC1 with CRC node metastasis (Begg's test p = 0.729, Egger's test p = 0.000). CONCLUSIONS: Despite of some modest bias, the pooled evidence suggested that MUC1 expression was significantly correlated with CRC metastasis.
  • |*Gene Expression Regulation, Neoplastic [MESH]
  • |Biomarkers, Tumor/*biosynthesis [MESH]
  • |Colorectal Neoplasms/*metabolism/*pathology [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Mucin-1/*biosynthesis [MESH]
  • |Neoplasm Metastasis [MESH]


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