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2015 ; 10
(9
): e0138049
Nephropedia Template TP
gab.com Text
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English Wikipedia
MUC1 Predicts Colorectal Cancer Metastasis: A Systematic Review and Meta-Analysis
of Case Controlled Studies
#MMPMID26367866
Zeng Y
; Zhang Q
; Zhang Y
; Lu M
; Liu Y
; Zheng T
; Feng S
; Hao M
; Shi H
PLoS One
2015[]; 10
(9
): e0138049
PMID26367866
show ga
OBJECTIVE: To evaluate the predicting value of MUC1 expression in lymph node and
distant metastasis of colorectal cancer (CRC). METHODS: Pubmed/ MEDLINE and
EMBASE were searched to identify eligible studies that evaluated the correlation
between MUC1 and CRC. A meta-analysis was conducted to evaluate the impact of
MUC1 expression on CRC metastasis. RESULTS: A total of 18 studies (n = 3271) met
inclusion criteria and the mean Newcastle-Ottawa Scale (NOS) score was 6.3 with a
range from 4 to 8. The pooled OR in the meta-analysis of 15 studies indicated
that positive MUC1 expression correlated with more CRC node metastasis (OR =
2.32, 95% CI = 1.63-3.29). The data synthesis of 6 studies suggested that MUC1
expression predicted more possibility of CRC distant metastasis (OR = 2.22, 95%
CI = 1.23-4.00). In addition, the combined OR of 7 studies showed that MUC1
expression indicated higher Duke's stage (OR = 3.02, 95% CI = 2.11-4.33). No
publication bias was found in the mate-analysis by Begg's test or Egger's test
with the exception of the meta-analysis of MUC1 with CRC node metastasis (Begg's
test p = 0.729, Egger's test p = 0.000). CONCLUSIONS: Despite of some modest
bias, the pooled evidence suggested that MUC1 expression was significantly
correlated with CRC metastasis.