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10.1091/mbc.E15-03-0142 http://scihub22266oqcxt.onion/10.1091/mbc.E15-03-0142 C4569314!4569314 !26224308     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26224308 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Biol+Cell 2015 ; 26 (18 ): 3229-44 Nephropedia Template TP {{tp|p=26224308 |t=2015. Src and cortactin promote lamellipodia protrusion and filopodia formation and stability in growth cones |pdf=|usr=}}{{26224308 }} gab.com Text Src and cortactin promote lamellipodia protrusion and filopodia formation and stability in growth cones JO: Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26224308 #FOAvip Src tyrosine kinases have been implicated in axonal growth and guidance; however, the underlying cellular mechanisms are not well understood. Specifically, it is unclear which aspects of actin organization and dynamics are regulated by Src in neuronal growth cones. Here, we investigated the function of Src2 and one of its substrates, cortactin, in lamellipodia and filopodia of Aplysia growth cones. We found that up-regulation of Src2 activation state or cortactin increased lamellipodial length, protrusion time, and actin network density, whereas down-regulation had opposite effects. Furthermore, Src2 or cortactin up-regulation increased filopodial density, length, and protrusion time, whereas down-regulation promoted lateral movements of filopodia. Fluorescent speckle microscopy revealed that rates of actin assembly and retrograde flow were not affected in either case. In summary, our results support a model in which Src and cortactin regulate growth cone motility by increasing actin network density and protrusion persistence of lamellipodia by controlling the state of actin-driven protrusion versus retraction. In addition, both proteins promote the formation and stability of actin bundles in filopodia. Twit Text FOAVip Src and cortactin promote lamellipodia protrusion and filopodia formation and stability in growth cones ????Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26224308 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26224308 #FOAvip English Wikipedia <ref>{{Cite pmid|26224308 }}</ref> Src and cortactin promote lamellipodia protrusion and filopodia formation and stability in growth cones #MMPMID26224308 He Y ; Ren Y ; Wu B ; Decourt B ; Lee AC ; Taylor A ; Suter DM Mol Biol Cell 2015[Sep]; 26 (18 ): 3229-44 PMID26224308 show ga Src tyrosine kinases have been implicated in axonal growth and guidance; however, the underlying cellular mechanisms are not well understood. Specifically, it is unclear which aspects of actin organization and dynamics are regulated by Src in neuronal growth cones. Here, we investigated the function of Src2 and one of its substrates, cortactin, in lamellipodia and filopodia of Aplysia growth cones. We found that up-regulation of Src2 activation state or cortactin increased lamellipodial length, protrusion time, and actin network density, whereas down-regulation had opposite effects. Furthermore, Src2 or cortactin up-regulation increased filopodial density, length, and protrusion time, whereas down-regulation promoted lateral movements of filopodia. Fluorescent speckle microscopy revealed that rates of actin assembly and retrograde flow were not affected in either case. In summary, our results support a model in which Src and cortactin regulate growth cone motility by increasing actin network density and protrusion persistence of lamellipodia by controlling the state of actin-driven protrusion versus retraction. In addition, both proteins promote the formation and stability of actin bundles in filopodia. |Actins/metabolism [MESH] |Animals [MESH] |Aplysia/*cytology/*metabolism [MESH] |Axons/metabolism [MESH] |Cells, Cultured [MESH] |Cortactin/*metabolism [MESH] |Down-Regulation [MESH] |Growth Cones/*metabolism [MESH] |Pseudopodia/*metabolism [MESH] |Up-Regulation [MESH]Src and cortactin promote lamellipodia protrusion and filopodia format(epmc).pdf DeepDyve Pubget Overpricing