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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Viszeralmedizin
2015 ; 31
(3
): 185-8
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How to Diagnose Immunoglobulin G4-Associated Cholangitis: The Jack-of-All-Trades
in the Biliary Tract
#MMPMID26468313
Hubers LM
; Beuers U
Viszeralmedizin
2015[Jun]; 31
(3
): 185-8
PMID26468313
show ga
BACKGROUND: Immunoglobulin (Ig) G4-associated cholangitis (IAC) is an
inflammatory disorder of the biliary tract displaying characteristic features of
IgG4-related disease (IgG4-RD): elevation of IgG4 serum levels, infiltration of
IgG4+ plasma cells in the affected tissue, and good response to immunosuppressive
treatment. METHODS AND RESULTS: The clinical presentation of IAC is often
misleading, mimicking other diseases of the biliary tract such as
cholangiocarcinoma or primary and secondary sclerosing cholangitis. The HISORt
criteria form the cornerstone in the diagnosis of IAC, combining
histopathological (H), imaging (I), and serological (S) features including serum
IgG4, other organ manifestations (O) of IgG4-RD and response to treatment (Rt).
The accuracy of the HISORt criteria is limited. Novel diagnostic approaches are
under evaluation. CONCLUSION: More accurate biomarkers are needed to correctly
diagnose IgG4-RD and prevent misdiagnoses and unnecessary therapeutic
interventions.