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10.15252/emmm.201505061 http://scihub22266oqcxt.onion/10.15252/emmm.201505061 C4568953!4568953!26194911     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Mol+Med 2015 ; 7 (9): 1211-28 Nephropedia Template TP {{tp|p=26194911|t=2015. Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms |pdf=|usr=}}{{26194911}} gab.com Text Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26194911 #FOAvip Genetic loss of collagen VII causes recessive dystrophic epidermolysis bullosa (RDEB)?a severe skin fragility disorder associated with lifelong blistering and disabling progressive soft tissue fibrosis. Causative therapies for this complex disorder face major hurdles, and clinical implementation remains elusive. Here, we report an alternative evidence-based approach to ameliorate fibrosis and relieve symptoms in RDEB. Based on the findings that TGF-? activity is elevated in injured RDEB skin, we targeted TGF-? activity with losartan in a preclinical setting. Long-term treatment of RDEB mice efficiently reduced TGF-? signaling in chronically injured forepaws and halted fibrosis and subsequent fusion of the digits. In addition, proteomics analysis of losartan- vs. vehicle-treated RDEB skin uncovered changes in multiple proteins related to tissue inflammation. In line with this, losartan reduced inflammation and diminished TNF-? and IL-6 expression in injured forepaws. Collectively, the data argue that RDEB fibrosis is a consequence of a cascade encompassing tissue damage, TGF-?-mediated inflammation, and matrix remodeling. Inhibition of TGF-? activity limits these unwanted outcomes and thereby substantially ameliorates long-term symptoms. Twit Text FOAVip Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26194911 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26194911 #FOAvip English Wikipedia <ref>{{Cite pmid|26194911}}</ref> Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms #MMPMID26194911 Nyström A; Thriene K; Mittapalli V; Kern JS; Kiritsi D; Dengjel J; Bruckner-Tuderman L EMBO Mol Med 2015[Sep]; 7 (9): 1211-28 PMID26194911show ga Genetic loss of collagen VII causes recessive dystrophic epidermolysis bullosa (RDEB)?a severe skin fragility disorder associated with lifelong blistering and disabling progressive soft tissue fibrosis. Causative therapies for this complex disorder face major hurdles, and clinical implementation remains elusive. Here, we report an alternative evidence-based approach to ameliorate fibrosis and relieve symptoms in RDEB. Based on the findings that TGF-? activity is elevated in injured RDEB skin, we targeted TGF-? activity with losartan in a preclinical setting. Long-term treatment of RDEB mice efficiently reduced TGF-? signaling in chronically injured forepaws and halted fibrosis and subsequent fusion of the digits. In addition, proteomics analysis of losartan- vs. vehicle-treated RDEB skin uncovered changes in multiple proteins related to tissue inflammation. In line with this, losartan reduced inflammation and diminished TNF-? and IL-6 expression in injured forepaws. Collectively, the data argue that RDEB fibrosis is a consequence of a cascade encompassing tissue damage, TGF-?-mediated inflammation, and matrix remodeling. Inhibition of TGF-? activity limits these unwanted outcomes and thereby substantially ameliorates long-term symptoms. äLosartan ameliorates dystrophic epidermolysis bullosa and uncovers new(epmc).pdf DeepDyve Pubget Overpricing