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10.15252/emmm.201504395 http://scihub22266oqcxt.onion/10.15252/emmm.201504395 C4568945!4568945 !26183451     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26183451 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+Mol+Med 2015 ; 7 (9 ): 1090-103 Nephropedia Template TP {{tp|p=26183451 |t=2015. Reprogramming and transdifferentiation for cardiovascular development and regenerative medicine: where do we stand? |pdf=|usr=}}{{26183451 }} gab.com Text Reprogramming and transdifferentiation for cardiovascular development and regenerative medicine: where do we stand JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26183451 #FOAvip Heart disease remains a leading cause of mortality and a major worldwide healthcare burden. Recent advances in stem cell biology have made it feasible to derive large quantities of cardiomyocytes for disease modeling, drug development, and regenerative medicine. The discoveries of reprogramming and transdifferentiation as novel biological processes have significantly contributed to this paradigm. This review surveys the means by which reprogramming and transdifferentiation can be employed to generate induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) and induced cardiomyocytes (iCMs). The application of these patient-specific cardiomyocytes for both in vitro disease modeling and in vivo therapies for various cardiovascular diseases will also be discussed. We propose that, with additional refinement, human disease-specific cardiomyocytes will allow us to significantly advance the understanding of cardiovascular disease mechanisms and accelerate the development of novel therapeutic options. Twit Text FOAVip Reprogramming and transdifferentiation for cardiovascular development and regenerative medicine: where do we stand ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26183451 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26183451 #FOAvip English Wikipedia <ref>{{Cite pmid|26183451 }}</ref> Reprogramming and transdifferentiation for cardiovascular development and regenerative medicine: where do we stand? #MMPMID26183451 Ebert AD ; Diecke S ; Chen IY ; Wu JC EMBO Mol Med 2015[Sep]; 7 (9 ): 1090-103 PMID26183451 show ga Heart disease remains a leading cause of mortality and a major worldwide healthcare burden. Recent advances in stem cell biology have made it feasible to derive large quantities of cardiomyocytes for disease modeling, drug development, and regenerative medicine. The discoveries of reprogramming and transdifferentiation as novel biological processes have significantly contributed to this paradigm. This review surveys the means by which reprogramming and transdifferentiation can be employed to generate induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) and induced cardiomyocytes (iCMs). The application of these patient-specific cardiomyocytes for both in vitro disease modeling and in vivo therapies for various cardiovascular diseases will also be discussed. We propose that, with additional refinement, human disease-specific cardiomyocytes will allow us to significantly advance the understanding of cardiovascular disease mechanisms and accelerate the development of novel therapeutic options. |*Cell Transdifferentiation [MESH] |Animals [MESH] |Biomedical Research/methods/trends [MESH] |Cardiovascular Diseases/*therapy [MESH] |Disease Models, Animal [MESH] |Humans [MESH] |Myocytes, Cardiac/*physiology [MESH] |Regenerative Medicine/*methods/*trends [MESH]Reprogramming and transdifferentiation for cardiovascular development (epmc).pdf DeepDyve Pubget Overpricing