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10.1111/jcmm.12619 http://scihub22266oqcxt.onion/10.1111/jcmm.12619 C4568931!4568931 !26103809     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26103809 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Mol+Med 2015 ; 19 (9 ): 2273-85 Nephropedia Template TP {{tp|p=26103809 |t=2015. Apelin promotes diabetic nephropathy by inducing podocyte dysfunction via inhibiting proteasome activities |pdf=|usr=}}{{26103809 }} gab.com Text Apelin promotes diabetic nephropathy by inducing podocyte dysfunction via inhibiting proteasome activities JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26103809 #FOAvip Podocyte injuries are associated with progression of diabetic nephropathy (DN). Apelin, an adipocyte-derived peptide, has been reported to be a promoting factor for DN. In this study, we aim to determine whether apelin promotes progression of DN by inducing podocyte dysfunction. kk-Ay mice were used as models for DN. Apelin and its antagonist, F13A were intraperitoneally administered for 4 weeks, respectively. Renal function and foot process proteins were analysed to evaluate the effects of apelin on kk-Ay mice and podocytes. Apelin increased albuminuria and decreased podocyte foot process proteins expression in kk-Ay mice, which is consistent with the results that apelin receptor (APLNR) levels increased in glomeruli of patients or mice with DN. In cultured podocytes, high glucose increased APLNR expression and apelin administration was associated with increased permeability and decreased foot process proteins levels. All these dysfunctions were associated with decreased 26S proteasome activities and increased polyubiquitinated proteins in both kk-Ay mice and cultured podocytes, as demonstrated by 26S proteasome activation with cyclic adenosine monophosphate (cAMP) or oleuropein. These effects seemed to be related to endoplasmic reticulum (ER) stress, as apelin increased C/EBP homologous protein (CHOP) and peiF? levels while cAMP or oleuropein reduced it in high glucose and apelin treated podocytes. These results suggest that apelin induces podocyte dysfunction in DN through ER stress which was induced by decreased proteasome activities in podocytes. Twit Text FOAVip Apelin promotes diabetic nephropathy by inducing podocyte dysfunction via inhibiting proteasome activities ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26103809 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26103809 #FOAvip English Wikipedia <ref>{{Cite pmid|26103809 }}</ref> Apelin promotes diabetic nephropathy by inducing podocyte dysfunction via inhibiting proteasome activities #MMPMID26103809 Guo C ; Liu Y ; Zhao W ; Wei S ; Zhang X ; Wang W ; Zeng X J Cell Mol Med 2015[Sep]; 19 (9 ): 2273-85 PMID26103809 show ga Podocyte injuries are associated with progression of diabetic nephropathy (DN). Apelin, an adipocyte-derived peptide, has been reported to be a promoting factor for DN. In this study, we aim to determine whether apelin promotes progression of DN by inducing podocyte dysfunction. kk-Ay mice were used as models for DN. Apelin and its antagonist, F13A were intraperitoneally administered for 4 weeks, respectively. Renal function and foot process proteins were analysed to evaluate the effects of apelin on kk-Ay mice and podocytes. Apelin increased albuminuria and decreased podocyte foot process proteins expression in kk-Ay mice, which is consistent with the results that apelin receptor (APLNR) levels increased in glomeruli of patients or mice with DN. In cultured podocytes, high glucose increased APLNR expression and apelin administration was associated with increased permeability and decreased foot process proteins levels. All these dysfunctions were associated with decreased 26S proteasome activities and increased polyubiquitinated proteins in both kk-Ay mice and cultured podocytes, as demonstrated by 26S proteasome activation with cyclic adenosine monophosphate (cAMP) or oleuropein. These effects seemed to be related to endoplasmic reticulum (ER) stress, as apelin increased C/EBP homologous protein (CHOP) and peiF? levels while cAMP or oleuropein reduced it in high glucose and apelin treated podocytes. These results suggest that apelin induces podocyte dysfunction in DN through ER stress which was induced by decreased proteasome activities in podocytes. |Albumins/metabolism [MESH] |Animals [MESH] |Apelin Receptors [MESH] |Basement Membrane/drug effects/pathology [MESH] |Cell Membrane Permeability/drug effects [MESH] |Creatinine/metabolism [MESH] |Cyclic AMP/pharmacology [MESH] |Diabetes Mellitus, Type 2/pathology/physiopathology [MESH] |Diabetic Nephropathies/*pathology/*physiopathology [MESH] |Endoplasmic Reticulum Stress/drug effects [MESH] |Female [MESH] |Glucose/pharmacology [MESH] |Humans [MESH] |Intercellular Signaling Peptides and Proteins/*adverse effects [MESH] |Iridoid Glucosides [MESH] |Iridoids/pharmacology [MESH] |Kidney Function Tests [MESH] |Kidney/drug effects/metabolism/physiopathology [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Middle Aged [MESH] |Podocytes/drug effects/*pathology [MESH] |Proteasome Endopeptidase Complex/*metabolism [MESH] |Proteasome Inhibitors/*pharmacology [MESH]Apelin promotes diabetic nephropathy by inducing podocyte dysfunction (epmc).pdf DeepDyve Pubget Overpricing