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10.1111/jcmm.12609 http://scihub22266oqcxt.onion/10.1111/jcmm.12609 C4568926!4568926 !26119034     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26119034 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Mol+Med 2015 ; 19 (9 ): 2215-31 Nephropedia Template TP {{tp|p=26119034 |t=2015. Astaxanthin prevents pulmonary fibrosis by promoting myofibroblast apoptosis dependent on Drp1-mediated mitochondrial fission |pdf=|usr=}}{{26119034 }} gab.com Text Astaxanthin prevents pulmonary fibrosis by promoting myofibroblast apoptosis dependent on Drp1-mediated mitochondrial fission JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26119034 #FOAvip Promotion of myofibroblast apoptosis is a potential therapeutic strategy for pulmonary fibrosis. This study investigated the antifibrotic effect of astaxanthin on the promotion of myofibroblast apoptosis based on dynamin-related protein-1 (Drp1)-mediated mitochondrial fission in vivo and in vitro. Results showed that astaxanthin can inhibit lung parenchymal distortion and collagen deposition, as well as promote myofibroblast apoptosis. Astaxanthin demonstrated pro-apoptotic function in myofibroblasts by contributing to mitochondrial fission, thereby leading to apoptosis by increasing the Drp1 expression and enhancing Drp1 translocation into the mitochondria. Two specific siRNAs were used to demonstrate that Drp1 is necessary to promote astaxanthin-induced mitochondrial fission and apoptosis in myofibroblasts. Drp1-associated genes, such as Bcl-2-associated X protein, cytochrome c, tumour suppressor gene p53 and p53-up-regulated modulator of apoptosis, were highly up-regulated in the astaxanthin group compared with those in the sham group. This study revealed that astaxanthin can prevent pulmonary fibrosis by promoting myofibroblast apoptosis through a Drp1-dependent molecular pathway. Furthermore, astaxanthin provides a potential therapeutic value in pulmonary fibrosis treatment. Twit Text FOAVip Astaxanthin prevents pulmonary fibrosis by promoting myofibroblast apoptosis dependent on Drp1-mediated mitochondrial fission ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26119034 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26119034 #FOAvip English Wikipedia <ref>{{Cite pmid|26119034 }}</ref> Astaxanthin prevents pulmonary fibrosis by promoting myofibroblast apoptosis dependent on Drp1-mediated mitochondrial fission #MMPMID26119034 Zhang J ; Xu P ; Wang Y ; Wang M ; Li H ; Lin S ; Mao C ; Wang B ; Song X ; Lv C J Cell Mol Med 2015[Sep]; 19 (9 ): 2215-31 PMID26119034 show ga Promotion of myofibroblast apoptosis is a potential therapeutic strategy for pulmonary fibrosis. This study investigated the antifibrotic effect of astaxanthin on the promotion of myofibroblast apoptosis based on dynamin-related protein-1 (Drp1)-mediated mitochondrial fission in vivo and in vitro. Results showed that astaxanthin can inhibit lung parenchymal distortion and collagen deposition, as well as promote myofibroblast apoptosis. Astaxanthin demonstrated pro-apoptotic function in myofibroblasts by contributing to mitochondrial fission, thereby leading to apoptosis by increasing the Drp1 expression and enhancing Drp1 translocation into the mitochondria. Two specific siRNAs were used to demonstrate that Drp1 is necessary to promote astaxanthin-induced mitochondrial fission and apoptosis in myofibroblasts. Drp1-associated genes, such as Bcl-2-associated X protein, cytochrome c, tumour suppressor gene p53 and p53-up-regulated modulator of apoptosis, were highly up-regulated in the astaxanthin group compared with those in the sham group. This study revealed that astaxanthin can prevent pulmonary fibrosis by promoting myofibroblast apoptosis through a Drp1-dependent molecular pathway. Furthermore, astaxanthin provides a potential therapeutic value in pulmonary fibrosis treatment. |*Mitochondrial Dynamics/drug effects [MESH] |Animals [MESH] |Apoptosis Regulatory Proteins/genetics/metabolism [MESH] |Apoptosis/*drug effects [MESH] |Cell Count [MESH] |Cell Line, Tumor [MESH] |Disease Models, Animal [MESH] |Dynamins [MESH] |GTP Phosphohydrolases/*metabolism [MESH] |Gene Expression Regulation, Neoplastic/drug effects [MESH] |Humans [MESH] |Microtubule-Associated Proteins/*metabolism [MESH] |Mitochondrial Proteins/*metabolism [MESH] |Myofibroblasts/drug effects/*pathology/ultrastructure [MESH] |Protein Transport/drug effects [MESH] |Proto-Oncogene Proteins/genetics/metabolism [MESH] |Pulmonary Fibrosis/*drug therapy/pathology/*prevention & control [MESH] |Rats, Sprague-Dawley [MESH] |Tumor Suppressor Protein p53/genetics/metabolism [MESH] |Xanthophylls/pharmacology/therapeutic use [MESH]Astaxanthin prevents pulmonary fibrosis by promoting myofibroblast apo(epmc).pdf DeepDyve Pubget Overpricing