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10.1016/j.ppedcard.2015.01.002 http://scihub22266oqcxt.onion/10.1016/j.ppedcard.2015.01.002 C4568836!4568836!26380542     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Prog+Pediatr+Cardiol 2015 ; 39 (1): 13-9 Nephropedia Template TP {{tp|p=26380542|t=2015. Cardiomyopathies in Noonan syndrome and the other RASopathies |pdf=|usr=}}{{26380542}} gab.com Text Cardiomyopathies in Noonan syndrome and the other RASopathies JO: Prog Pediatr Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=26380542 #FOAvip Noonan syndrome and related disorders (Noonan syndrome with multiple lentigines, Costello syndrome, cardiofaciocutaneous syndrome, Noonan syndrome with loose anagen hair, and other related traits) are autosomal dominant traits. Mutations causing these disorders alter proteins relevant for signaling through RAS. Thus, these traits are now collectively called the RASopathies. While the RASopathies have pleiomorphic features, this review will focus on the hypertrophic cardiomyopathy observed in varying percentages of all of these traits. In addition, inherited abnormalities in one pathway gene, RAF1, cause pediatric-onset dilated cardiomyopathy. The pathogeneses for the RASopathy-associated cardiomyopathies are being elucidated, principally using animal models, leading to genotype-specific insights into how signal transduction is perturbed. Based on those findings, small molecule therapies seem possible for RASopathy-associated cardiomyopathies. Twit Text FOAVip Cardiomyopathies in Noonan syndrome and the other RASopathies ????Prog Pediatr Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=26380542 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26380542 #FOAvip English Wikipedia <ref>{{Cite pmid|26380542}}</ref> Cardiomyopathies in Noonan syndrome and the other RASopathies #MMPMID26380542 Gelb BD; Roberts AE; Tartaglia M Prog Pediatr Cardiol 2015[Jul]; 39 (1): 13-9 PMID26380542show ga Noonan syndrome and related disorders (Noonan syndrome with multiple lentigines, Costello syndrome, cardiofaciocutaneous syndrome, Noonan syndrome with loose anagen hair, and other related traits) are autosomal dominant traits. Mutations causing these disorders alter proteins relevant for signaling through RAS. Thus, these traits are now collectively called the RASopathies. While the RASopathies have pleiomorphic features, this review will focus on the hypertrophic cardiomyopathy observed in varying percentages of all of these traits. In addition, inherited abnormalities in one pathway gene, RAF1, cause pediatric-onset dilated cardiomyopathy. The pathogeneses for the RASopathy-associated cardiomyopathies are being elucidated, principally using animal models, leading to genotype-specific insights into how signal transduction is perturbed. Based on those findings, small molecule therapies seem possible for RASopathy-associated cardiomyopathies. äCardiomyopathies in Noonan syndrome and the other RASopathies (epmc).pdf DeepDyve Pubget Overpricing