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http://scihub22266oqcxt.onion/ C4568791!4568791!26396666     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Transl+Res 2015 ; 7 (8): 1345-56 Nephropedia Template TP {{tp|p=26396666|t=2015. Role of SDF-1 and Wnt signaling pathway in the myocardial fibrosis of hypertensive rats |pdf=|usr=}}{{26396666}} gab.com Text Role of SDF-1 and Wnt signaling pathway in the myocardial fibrosis of hypertensive rats JO: Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=26396666 #FOAvip Objective: To investigate the effects of stromal cell-derived factor-1 (SDF-1) and Wnt signaling pathway on the bioactivities of myofibroblasts (MFs) and the expressions of SDF-1 and components of Wnt signaling pathway in the myocardium of spontaneously hypertensive rats (SHR). Methods: BMSCs were induced to differentiate into MFs in vitro, and SDF-1 and Wnt signaling pathway were independently or simultaneously blocked. Then, the migration of MFs and the secretion of Col I and ?-SMA were determined in MFs. Heart function, progression of myocardial fibrosis and structure of the heart were evaluated. The expression of SDF-1 and components of Wnt signaling pathway in SHR was detected. Results: TGF-? could induce the differentiation of BMSCs into B-MFs; Blocking SDF-1/CXCR4 axis and/or Wnt signaling pathway was able to inhibit the MFs migration and Col I secretion; Blocking Wnt signaling pathway inhibited the differentiation of BMSCs into MFs; Serum SDF-1 increased with the increase in blood pressure, and serum ?-catenin elevated with the fluctuation of blood pressure; Protein and mRNA expressions of SDF-1 in the myocardium increased, and those of DKK-1 (an inhibitor of Wnt signaling pathway) and GSK-3 reduced in SHR. Conclusion: SDF-1 and Wnt signaling pathway are involved in the differentiation of BMSCs into MFs, as well as the migration and collagen secretion of MFs; Hypertension affects the expressions of SDF-1 and components of Wnt signaling pathway. In the myocardium of SHR, SDF-1 expression increases, but the expression of inhibitor of Wnt signaling pathway reduces. Twit Text FOAVip Role of SDF-1 and Wnt signaling pathway in the myocardial fibrosis of hypertensive rats ????Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=26396666 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26396666 #FOAvip English Wikipedia <ref>{{Cite pmid|26396666}}</ref> Role of SDF-1 and Wnt signaling pathway in the myocardial fibrosis of hypertensive rats #MMPMID26396666 Shao S; Cai W; Sheng J; Yin L Am J Transl Res 2015[]; 7 (8): 1345-56 PMID26396666show ga Objective: To investigate the effects of stromal cell-derived factor-1 (SDF-1) and Wnt signaling pathway on the bioactivities of myofibroblasts (MFs) and the expressions of SDF-1 and components of Wnt signaling pathway in the myocardium of spontaneously hypertensive rats (SHR). Methods: BMSCs were induced to differentiate into MFs in vitro, and SDF-1 and Wnt signaling pathway were independently or simultaneously blocked. Then, the migration of MFs and the secretion of Col I and ?-SMA were determined in MFs. Heart function, progression of myocardial fibrosis and structure of the heart were evaluated. The expression of SDF-1 and components of Wnt signaling pathway in SHR was detected. Results: TGF-? could induce the differentiation of BMSCs into B-MFs; Blocking SDF-1/CXCR4 axis and/or Wnt signaling pathway was able to inhibit the MFs migration and Col I secretion; Blocking Wnt signaling pathway inhibited the differentiation of BMSCs into MFs; Serum SDF-1 increased with the increase in blood pressure, and serum ?-catenin elevated with the fluctuation of blood pressure; Protein and mRNA expressions of SDF-1 in the myocardium increased, and those of DKK-1 (an inhibitor of Wnt signaling pathway) and GSK-3 reduced in SHR. Conclusion: SDF-1 and Wnt signaling pathway are involved in the differentiation of BMSCs into MFs, as well as the migration and collagen secretion of MFs; Hypertension affects the expressions of SDF-1 and components of Wnt signaling pathway. In the myocardium of SHR, SDF-1 expression increases, but the expression of inhibitor of Wnt signaling pathway reduces. äRole of SDF-1 and Wnt signaling pathway in the myocardial fibrosis of (epmc).pdf DeepDyve Pubget Overpricing