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10.2174/1381612819666131118203641 http://scihub22266oqcxt.onion/10.2174/1381612819666131118203641 C4568743!4568743 !24245756     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24245756 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Pharm+Des 2014 ; 20 (27 ): 4357-78 Nephropedia Template TP {{tp|p=24245756 |t=2014. New approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics |pdf=|usr=}}{{24245756 }} gab.com Text New approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics JO: Curr Pharm Des http://www.kidney.de/pget.php?&tw=1&pmid=24245756 #FOAvip Mycolic acids are the major lipid components of the unique mycobacterial cell wall responsible for the protection of the tuberculosis bacilli from many outside threats. Mycolic acids are synthesized in the cytoplasm and transported to the outer membrane as trehalose- containing glycolipids before being esterified to the arabinogalactan portion of the cell wall and outer membrane glycolipids. The large size of these unique fatty acids is a result of a huge metabolic investment that has been evolutionarily conserved, indicating the importance of these lipids to the mycobacterial cellular survival. There are many key enzymes involved in the mycolic acid biosynthetic pathway, including fatty acid synthesis (KasA, KasB, MabA, InhA, HadABC), mycolic acid modifying enzymes (SAM-dependent methyltransferases, aNAT), fatty acid activating and condensing enzymes (FadD32, Acc, Pks13), transporters (MmpL3) and tranferases (Antigen 85A-C) all of which are excellent potential drug targets. Not surprisingly, in recent years many new compounds have been reported to inhibit specific portions of this pathway, discovered through both phenotypic screening and target enzyme screening. In this review, we analyze the new and emerging inhibitors of this pathway discovered in the post-genomic era of tuberculosis drug discovery, several of which show great promise as selective tuberculosis therapeutics. Twit Text FOAVip New approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics ????Curr Pharm Des http://www.kidney.de/pget.php?&tw=1&pmid=24245756 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24245756 #FOAvip English Wikipedia <ref>{{Cite pmid|24245756 }}</ref> New approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics #MMPMID24245756 North EJ ; Jackson M ; Lee RE Curr Pharm Des 2014[]; 20 (27 ): 4357-78 PMID24245756 show ga Mycolic acids are the major lipid components of the unique mycobacterial cell wall responsible for the protection of the tuberculosis bacilli from many outside threats. Mycolic acids are synthesized in the cytoplasm and transported to the outer membrane as trehalose- containing glycolipids before being esterified to the arabinogalactan portion of the cell wall and outer membrane glycolipids. The large size of these unique fatty acids is a result of a huge metabolic investment that has been evolutionarily conserved, indicating the importance of these lipids to the mycobacterial cellular survival. There are many key enzymes involved in the mycolic acid biosynthetic pathway, including fatty acid synthesis (KasA, KasB, MabA, InhA, HadABC), mycolic acid modifying enzymes (SAM-dependent methyltransferases, aNAT), fatty acid activating and condensing enzymes (FadD32, Acc, Pks13), transporters (MmpL3) and tranferases (Antigen 85A-C) all of which are excellent potential drug targets. Not surprisingly, in recent years many new compounds have been reported to inhibit specific portions of this pathway, discovered through both phenotypic screening and target enzyme screening. In this review, we analyze the new and emerging inhibitors of this pathway discovered in the post-genomic era of tuberculosis drug discovery, several of which show great promise as selective tuberculosis therapeutics. |Antitubercular Agents/chemistry/*pharmacology [MESH] |Bacterial Proteins/antagonists & inhibitors [MESH] |Biosynthetic Pathways/*drug effects [MESH] |Cell Wall/drug effects/enzymology/metabolism [MESH] |Drug Discovery/*methods [MESH] |Enzyme Inhibitors/chemistry/*pharmacology [MESH] |Microbial Sensitivity Tests [MESH] |Molecular Structure [MESH] |Mycobacterium tuberculosis/*drug effects/enzymology/metabolism [MESH]New approaches to target the mycolic acid biosynthesis pathway for the(epmc).pdf DeepDyve Pubget Overpricing