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10.1073/pnas.1502029112 http://scihub22266oqcxt.onion/10.1073/pnas.1502029112 C4568679!4568679!26305930     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (36): 11258-63 Nephropedia Template TP {{tp|p=26305930|t=2015. Mechanical control of mitotic progression in single animal cells |pdf=|usr=}}{{26305930}} gab.com Text Mechanical control of mitotic progression in single animal cells JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26305930 #FOAvip In animal tissue, most adherent cells round up against confinement to conduct mitosis. Impaired cell rounding is thought to perturb tissue development and homeostasis and contribute to progression of cancer. Due to the lack of suitable experimental tools, however, insight into the mechanical robustness of mitosis in animal cells remains limited. Here we introduce force-feedback?controlled ion beam-sculpted cantilevers to confine single cells and characterize their progression through mitosis. Our approach reveals critical yield forces that trigger cell cortex herniation, loss of F-actin homogeneity, dissipation of intracellular pressure, critical cell-height decrease, mitotic spindle defects, and resultant perturbation of mitotic progression. Twit Text FOAVip Mechanical control of mitotic progression in single animal cells ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26305930 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26305930 #FOAvip English Wikipedia <ref>{{Cite pmid|26305930}}</ref> Mechanical control of mitotic progression in single animal cells #MMPMID26305930 Cattin CJ; Düggelin M; Martinez-Martin D; Gerber C; Müller DJ; Stewart MP Proc Natl Acad Sci U S A 2015[Sep]; 112 (36): 11258-63 PMID26305930show ga In animal tissue, most adherent cells round up against confinement to conduct mitosis. Impaired cell rounding is thought to perturb tissue development and homeostasis and contribute to progression of cancer. Due to the lack of suitable experimental tools, however, insight into the mechanical robustness of mitosis in animal cells remains limited. Here we introduce force-feedback?controlled ion beam-sculpted cantilevers to confine single cells and characterize their progression through mitosis. Our approach reveals critical yield forces that trigger cell cortex herniation, loss of F-actin homogeneity, dissipation of intracellular pressure, critical cell-height decrease, mitotic spindle defects, and resultant perturbation of mitotic progression. äMechanical control of mitotic progression in single animal cells (epmc).pdf DeepDyve Pubget Overpricing