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10.1155/2015/736104 http://scihub22266oqcxt.onion/10.1155/2015/736104 C4568328!4568328!26417600     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=26417600|t=2015. Role and Importance of IGF-1 in Traumatic Brain Injuries |pdf=|usr=}}{{26417600}} gab.com Text Role and Importance of IGF-1 in Traumatic Brain Injuries JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26417600 #FOAvip It is increasingly affirmed that most of the long-term consequences of TBI are due to molecular and cellular changes occurring during the acute phase of the injury and which may, afterwards, persist or progress. Understanding how to prevent secondary damage and improve outcome in trauma patients, has been always a target of scientific interest. Plans of studies focused their attention on the posttraumatic neuroendocrine dysfunction in order to achieve a correlation between hormone blood level and TBI outcomes. The somatotropic axis (GH and IGF-1) seems to be the most affected, with different alterations between the acute and late phases. IGF-1 plays an important role in brain growth and development, and it is related to repair responses to damage for both the central and peripheral nervous system. The IGF-1 blood levels result prone to decrease during both the early and late phases after TBI. Despite this, experimental studies on animals have shown that the CNS responds to the injury upregulating the expression of IGF-1; thus it appears to be related to the secondary mechanisms of response to posttraumatic damage. We review the mechanisms involving IGF-1 in TBI, analyzing how its expression and metabolism may affect prognosis and outcome in head trauma patients. Twit Text FOAVip Role and Importance of IGF-1 in Traumatic Brain Injuries ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26417600 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26417600 #FOAvip English Wikipedia <ref>{{Cite pmid|26417600}}</ref> Role and Importance of IGF-1 in Traumatic Brain Injuries #MMPMID26417600 Mangiola A; Vigo V; Anile C; De Bonis P; Marziali G; Lofrese G Biomed Res Int 2015[]; 2015 (ä): ä PMID26417600show ga It is increasingly affirmed that most of the long-term consequences of TBI are due to molecular and cellular changes occurring during the acute phase of the injury and which may, afterwards, persist or progress. Understanding how to prevent secondary damage and improve outcome in trauma patients, has been always a target of scientific interest. Plans of studies focused their attention on the posttraumatic neuroendocrine dysfunction in order to achieve a correlation between hormone blood level and TBI outcomes. The somatotropic axis (GH and IGF-1) seems to be the most affected, with different alterations between the acute and late phases. IGF-1 plays an important role in brain growth and development, and it is related to repair responses to damage for both the central and peripheral nervous system. The IGF-1 blood levels result prone to decrease during both the early and late phases after TBI. Despite this, experimental studies on animals have shown that the CNS responds to the injury upregulating the expression of IGF-1; thus it appears to be related to the secondary mechanisms of response to posttraumatic damage. We review the mechanisms involving IGF-1 in TBI, analyzing how its expression and metabolism may affect prognosis and outcome in head trauma patients. äRole and Importance of IGF-1 in Traumatic Brain Injuries (epmc).pdf DeepDyve Pubget Overpricing