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10.1073/pnas.1504076112

http://scihub22266oqcxt.onion/10.1073/pnas.1504076112
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C4568218!4568218!26216986
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suck abstract from ncbi


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pmid26216986      Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (35): 11054-9
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  • Socially mediated induction and suppression of antibiosis during bacterial coexistence #MMPMID26216986
  • Abrudan MI; Smakman F; Grimbergen AJ; Westhoff S; Miller EL; van Wezel GP; Rozen DE
  • Proc Natl Acad Sci U S A 2015[Sep]; 112 (35): 11054-9 PMID26216986show ga
  • Antibiotics have profoundly changed human medicine, yet we know surprisingly little about the role of antibiotics in nature for the bacteria that produce them. Here we examine antibiotic use in the prolific antibiotic-producing genus Streptomyces across divergent social and competitive growth conditions. Our results provide clear experimental evidence that antibiotics are weapons whose use is strongly modified by intermicrobial social interactions. Simultaneously, using experiments and computer simulations, we show that social and competitive dynamics between bacteria have a crucial and previously unrecognized influence on the maintenance of microbial diversity in soil environments. These insights have implications for both bacterial coexistence and diversity and also for drug discovery.
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