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10.1016/j.jsbmb.2015.03.009 http://scihub22266oqcxt.onion/10.1016/j.jsbmb.2015.03.009 C4568128!4568128!25804222     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25804222&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Steroid+Biochem+Mol+Biol 2015 ; 153 (ä): 27-34 Nephropedia Template TP {{tp|p=25804222|t=2015. Glucocorticoid Signaling in the Heart: A Cardiomyocyte Perspective |pdf=|usr=}}{{25804222}} gab.com Text Glucocorticoid Signaling in the Heart: A Cardiomyocyte Perspective JO: J Steroid Biochem Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25804222 #FOAvip Heart failure is one of the leading causes of death in the Western world. Glucocorticoids are primary stress hormones that regulate a vast array of biological processes, and synthetic derivatives of these steroids have been mainstays in the clinic for the last half century. Abnormal levels of glucocorticoids are known to negatively impact the cardiovascular system; however, surprisingly little is known about the direct role of glucocorticoid signaling in the heart. The actions of glucocorticoids are mediated classically by the glucocorticoid receptor (GR). In certain cells, such as cardiomyocytes, glucocorticoid occupancy and activation of the mineralocorticoid receptor (MR) may also contribute to the observed response. Recently, there has been a surge of reports investigating the in vivo function of glucocorticoid signaling in the heart using transgenic mice that specifically target GR or MR in cardiomyocytes. Results from these studies suggest that GR signaling in cardiomyocytes is critical for the normal development and function of the heart. In contrast, MR signaling in cardiomyocytes participates in the development and progression of cardiac disease. In the following review, we discuss these genetic mouse models and the new insights they are providing into the direct role cardiomyocyte glucocorticoid signaling plays in heart physiology and pathophysiology. Twit Text FOAVip Glucocorticoid Signaling in the Heart: A Cardiomyocyte Perspective ????J Steroid Biochem Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25804222 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25804222 #FOAvip English Wikipedia <ref>{{Cite pmid|25804222}}</ref> Glucocorticoid Signaling in the Heart: A Cardiomyocyte Perspective #MMPMID25804222 Oakley RH; Cidlowski JA J Steroid Biochem Mol Biol 2015[Sep]; 153 (ä): 27-34 PMID25804222show ga Heart failure is one of the leading causes of death in the Western world. Glucocorticoids are primary stress hormones that regulate a vast array of biological processes, and synthetic derivatives of these steroids have been mainstays in the clinic for the last half century. Abnormal levels of glucocorticoids are known to negatively impact the cardiovascular system; however, surprisingly little is known about the direct role of glucocorticoid signaling in the heart. The actions of glucocorticoids are mediated classically by the glucocorticoid receptor (GR). In certain cells, such as cardiomyocytes, glucocorticoid occupancy and activation of the mineralocorticoid receptor (MR) may also contribute to the observed response. Recently, there has been a surge of reports investigating the in vivo function of glucocorticoid signaling in the heart using transgenic mice that specifically target GR or MR in cardiomyocytes. Results from these studies suggest that GR signaling in cardiomyocytes is critical for the normal development and function of the heart. In contrast, MR signaling in cardiomyocytes participates in the development and progression of cardiac disease. In the following review, we discuss these genetic mouse models and the new insights they are providing into the direct role cardiomyocyte glucocorticoid signaling plays in heart physiology and pathophysiology. äGlucocorticoid Signaling in the Heart: A Cardiomyocyte Perspective (epmc).pdf DeepDyve Pubget Overpricing