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10.1128/IAI.00803-15 http://scihub22266oqcxt.onion/10.1128/IAI.00803-15 C4567644!4567644 !26195547     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26195547 &cmd=llinks): Failed to open stream: HTTP request failed! 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Pseudomonas aeruginosa Quorum Sensing Molecule N-(3-Oxododecanoyl)-L-Homoserine-Lactone Induces HLA-G Expression in Human Immune Cells |pdf=|usr=}}{{26195547 }} gab.com Text Pseudomonas aeruginosa Quorum Sensing Molecule N-(3-Oxododecanoyl)-L-Homoserine-Lactone Induces HLA-G Expression in Human Immune Cells JO: Infect Immun http://www.kidney.de/pget.php?&tw=1&pmid=26195547 #FOAvip HLA-G is a nonclassical class I human leukocyte antigen (HLA) involved in mechanisms of immune tolerance. The objective of this study was to determine whether N-(3-oxododecanoyl)-l-homoserine lactone (3O-C12-HSL), a quorum sensing molecule produced by Pseudomonas aeruginosa, could modify HLA-G expression to control the host immune response. We evaluated the ability of 3O-C12-HSL to induce HLA-G expression in primary immune cells, monocytes (U937 and THP1), and T-cell lines (Jurkat) in vitro and analyzed the cellular pathway responsible for HLA-G expression. We studied the HLA-G promoter with a luciferase assay and interleukin-10 (IL-10) and p38/CREB signaling with enzyme-linked immunosorbent assay and immunofluorescence, respectively. We observed that 3O-C12-HSL is able to induce HLA-G expression in human monocytes and T cells. We showed that the induction of HLA-G by 3O-C12-HSL is p38/CREB and IL-10 dependent. 3O-C12-HSL treatment is able to arrest only the U937 cell cycle, possibly due to the peculiar expression of the ILT2 receptor in the U937 cell line. Our observations suggest HLA-G as a mechanism to create a protected niche for the bacterial reservoir, similar to the role of HLA-G molecules during viral infections. Twit Text FOAVip Pseudomonas aeruginosa Quorum Sensing Molecule N-(3-Oxododecanoyl)-L-Homoserine-Lactone Induces HLA-G Expression in Human Immune Cells ????Infect Immun http://www.kidney.de/pget.php?&tw=1&pmid=26195547 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26195547 #FOAvip English Wikipedia <ref>{{Cite pmid|26195547 }}</ref> Pseudomonas aeruginosa Quorum Sensing Molecule N-(3-Oxododecanoyl)-L-Homoserine-Lactone Induces HLA-G Expression in Human Immune Cells #MMPMID26195547 Bortolotti D ; LeMaoult J ; Trapella C ; Di Luca D ; Carosella ED ; Rizzo R Infect Immun 2015[Oct]; 83 (10 ): 3918-25 PMID26195547 show ga HLA-G is a nonclassical class I human leukocyte antigen (HLA) involved in mechanisms of immune tolerance. The objective of this study was to determine whether N-(3-oxododecanoyl)-l-homoserine lactone (3O-C12-HSL), a quorum sensing molecule produced by Pseudomonas aeruginosa, could modify HLA-G expression to control the host immune response. We evaluated the ability of 3O-C12-HSL to induce HLA-G expression in primary immune cells, monocytes (U937 and THP1), and T-cell lines (Jurkat) in vitro and analyzed the cellular pathway responsible for HLA-G expression. We studied the HLA-G promoter with a luciferase assay and interleukin-10 (IL-10) and p38/CREB signaling with enzyme-linked immunosorbent assay and immunofluorescence, respectively. We observed that 3O-C12-HSL is able to induce HLA-G expression in human monocytes and T cells. We showed that the induction of HLA-G by 3O-C12-HSL is p38/CREB and IL-10 dependent. 3O-C12-HSL treatment is able to arrest only the U937 cell cycle, possibly due to the peculiar expression of the ILT2 receptor in the U937 cell line. Our observations suggest HLA-G as a mechanism to create a protected niche for the bacterial reservoir, similar to the role of HLA-G molecules during viral infections. |*Quorum Sensing [MESH] |*Up-Regulation [MESH] |4-Butyrolactone/*analogs & derivatives/immunology/metabolism [MESH] |HLA-G Antigens/*genetics/immunology [MESH] |Homoserine/*analogs & derivatives/immunology/metabolism [MESH] |Humans [MESH] |Interleukin-10/genetics/immunology [MESH] |Monocytes/immunology [MESH] |Pseudomonas Infections/genetics/*immunology/microbiology [MESH] |Pseudomonas aeruginosa/genetics/immunology/*physiology [MESH] |T-Lymphocytes/immunology [MESH]Pseudomonas aeruginosa Quorum Sensing Molecule N-(3-Oxododecanoyl)-L(epmc).pdf DeepDyve Pubget Overpricing