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10.1128/IAI.00814-15 http://scihub22266oqcxt.onion/10.1128/IAI.00814-15 C4567637!4567637 !26259813     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26259813 &cmd=llinks): Failed to open stream: HTTP request failed! 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Comparative Genomic Analysis of Meningitis- and Bacteremia-Causing Pneumococci Identifies a Common Core Genome |pdf=|usr=}}{{26259813 }} gab.com Text Comparative Genomic Analysis of Meningitis- and Bacteremia-Causing Pneumococci Identifies a Common Core Genome JO: Infect Immun http://www.kidney.de/pget.php?&tw=1&pmid=26259813 #FOAvip Streptococcus pneumoniae is a nasopharyngeal commensal that occasionally invades normally sterile sites to cause bloodstream infection and meningitis. Although the pneumococcal population structure and evolutionary genetics are well defined, it is not clear whether pneumococci that cause meningitis are genetically distinct from those that do not. Here, we used whole-genome sequencing of 140 isolates of S. pneumoniae recovered from bloodstream infection (n = 70) and meningitis (n = 70) to compare their genetic contents. By fitting a double-exponential decaying-function model, we show that these isolates share a core of 1,427 genes (95% confidence interval [CI], 1,425 to 1,435 genes) and that there is no difference in the core genome or accessory gene content from these disease manifestations. Gene presence/absence alone therefore does not explain the virulence behavior of pneumococci that reach the meninges. Our analysis, however, supports the requirement of a range of previously described virulence factors and vaccine candidates for both meningitis- and bacteremia-causing pneumococci. This high-resolution view suggests that, despite considerable competency for genetic exchange, all pneumococci are under considerable pressure to retain key components advantageous for colonization and transmission and that these components are essential for access to and survival in sterile sites. Twit Text FOAVip Comparative Genomic Analysis of Meningitis- and Bacteremia-Causing Pneumococci Identifies a Common Core Genome ????Infect Immun http://www.kidney.de/pget.php?&tw=1&pmid=26259813 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26259813 #FOAvip English Wikipedia <ref>{{Cite pmid|26259813 }}</ref> Comparative Genomic Analysis of Meningitis- and Bacteremia-Causing Pneumococci Identifies a Common Core Genome #MMPMID26259813 Kulohoma BW ; Cornick JE ; Chaguza C ; Yalcin F ; Harris SR ; Gray KJ ; Kiran AM ; Molyneux E ; French N ; Parkhill J ; Faragher BE ; Everett DB ; Bentley SD ; Heyderman RS Infect Immun 2015[Oct]; 83 (10 ): 4165-73 PMID26259813 show ga Streptococcus pneumoniae is a nasopharyngeal commensal that occasionally invades normally sterile sites to cause bloodstream infection and meningitis. Although the pneumococcal population structure and evolutionary genetics are well defined, it is not clear whether pneumococci that cause meningitis are genetically distinct from those that do not. Here, we used whole-genome sequencing of 140 isolates of S. pneumoniae recovered from bloodstream infection (n = 70) and meningitis (n = 70) to compare their genetic contents. By fitting a double-exponential decaying-function model, we show that these isolates share a core of 1,427 genes (95% confidence interval [CI], 1,425 to 1,435 genes) and that there is no difference in the core genome or accessory gene content from these disease manifestations. Gene presence/absence alone therefore does not explain the virulence behavior of pneumococci that reach the meninges. Our analysis, however, supports the requirement of a range of previously described virulence factors and vaccine candidates for both meningitis- and bacteremia-causing pneumococci. This high-resolution view suggests that, despite considerable competency for genetic exchange, all pneumococci are under considerable pressure to retain key components advantageous for colonization and transmission and that these components are essential for access to and survival in sterile sites. |Bacteremia/*microbiology [MESH] |Bacterial Proteins/*genetics/metabolism [MESH] |Genome, Bacterial [MESH] |Genomics [MESH] |Humans [MESH] |Meningitis/*microbiology [MESH] |Streptococcal Infections/*microbiology [MESH]Comparative Genomic Analysis of Meningitis- and Bacteremia-Causing Pne(epmc).pdf DeepDyve Pubget Overpricing