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10.1128/IAI.00446-15 http://scihub22266oqcxt.onion/10.1128/IAI.00446-15 C4567633!4567633 !26169273     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26169273 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Infect+Immun 2015 ; 83 (10 ): 3816-24 Nephropedia Template TP {{tp|p=26169273 |t=2015. Phosphoantigen Burst upon Plasmodium falciparum Schizont Rupture Can Distantly Activate V?9V?2 T Cells |pdf=|usr=}}{{26169273 }} gab.com Text Phosphoantigen Burst upon Plasmodium falciparum Schizont Rupture Can Distantly Activate V 9V 2 T Cells JO: Infect Immun http://www.kidney.de/pget.php?&tw=1&pmid=26169273 #FOAvip Malaria induces potent activation and expansion of the V?9V?2 subpopulation of ??T cells, which inhibit the Plasmodium falciparum blood cycle through soluble cytotoxic mediators, abrogating merozoite invasion capacity. Intraerythrocytic stages efficiently trigger V?9V?2 T-cell activation and degranulation through poorly understood mechanisms. P. falciparum blood-stage extracts are known to contain phosphoantigens able to stimulate V?9V?2 T cells, but how these are presented by intact infected red blood cells (iRBCs) remains elusive. Here we show that, unlike activation by phosphoantigen-expressing cells, V?9V?2 T-cell activation by intact iRBCs is independent of butyrophilin expression by the iRBC, and contact with an intact iRBC is not required. Moreover, blood-stage culture supernatants proved to be as potent activators of V?9V?2 T cells as iRBCs. Bioactivity in the microenvironment is attributable to phosphoantigens, as it is dependent on the parasite DOXP pathway, on V?9V?2 TCR signaling, and on butyrophilin expression by V?9V?2 T cells. Kinetic studies showed that the phosphoantigens were released at the end of the intraerythrocytic cycle at the time of parasite egress. We document exquisite sensitivity of V?9V?2 T cells, which respond to a few thousand parasites. These data unravel a novel framework, whereby release of phosphoantigens into the extracellular milieu by sequestered parasites likely promotes activation of distant V?9V?2 T cells that in turn exert remote antiparasitic functions. Twit Text FOAVip Phosphoantigen Burst upon Plasmodium falciparum Schizont Rupture Can Distantly Activate V 9V 2 T Cells ????Infect Immun http://www.kidney.de/pget.php?&tw=1&pmid=26169273 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26169273 #FOAvip English Wikipedia <ref>{{Cite pmid|26169273 }}</ref> Phosphoantigen Burst upon Plasmodium falciparum Schizont Rupture Can Distantly Activate V?9V?2 T Cells #MMPMID26169273 Guenot M ; Loizon S ; Howard J ; Costa G ; Baker DA ; Mohabeer SY ; Troye-Blomberg M ; Moreau JF ; Déchanet-Merville J ; Mercereau-Puijalon O ; Mamani-Matsuda M ; Behr C Infect Immun 2015[Oct]; 83 (10 ): 3816-24 PMID26169273 show ga Malaria induces potent activation and expansion of the V?9V?2 subpopulation of ??T cells, which inhibit the Plasmodium falciparum blood cycle through soluble cytotoxic mediators, abrogating merozoite invasion capacity. Intraerythrocytic stages efficiently trigger V?9V?2 T-cell activation and degranulation through poorly understood mechanisms. P. falciparum blood-stage extracts are known to contain phosphoantigens able to stimulate V?9V?2 T cells, but how these are presented by intact infected red blood cells (iRBCs) remains elusive. Here we show that, unlike activation by phosphoantigen-expressing cells, V?9V?2 T-cell activation by intact iRBCs is independent of butyrophilin expression by the iRBC, and contact with an intact iRBC is not required. Moreover, blood-stage culture supernatants proved to be as potent activators of V?9V?2 T cells as iRBCs. Bioactivity in the microenvironment is attributable to phosphoantigens, as it is dependent on the parasite DOXP pathway, on V?9V?2 TCR signaling, and on butyrophilin expression by V?9V?2 T cells. Kinetic studies showed that the phosphoantigens were released at the end of the intraerythrocytic cycle at the time of parasite egress. We document exquisite sensitivity of V?9V?2 T cells, which respond to a few thousand parasites. These data unravel a novel framework, whereby release of phosphoantigens into the extracellular milieu by sequestered parasites likely promotes activation of distant V?9V?2 T cells that in turn exert remote antiparasitic functions. |Antigens, Protozoan/*immunology/metabolism [MESH] |Erythrocytes/parasitology [MESH] |Humans [MESH] |Lymphocyte Activation [MESH] |Malaria, Falciparum/*immunology/parasitology [MESH] |Merozoites/growth & development/immunology/physiology [MESH] |Phosphorylation [MESH] |Plasmodium falciparum/growth & development/*immunology/physiology [MESH] |Protozoan Proteins/*immunology/metabolism [MESH]Phosphoantigen Burst upon Plasmodium falciparum Schizont Rupture Can D(epmc).pdf DeepDyve Pubget Overpricing