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10.1016/j.celrep.2015.02.037 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.02.037 C4567551!4567551!25772353     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2015 ; 10 (10): 1655-64 Nephropedia Template TP {{tp|p=25772353|t=2015. A lupus-associated Mac-1 variant has defects in integrin allostery and interaction with ligands under force |pdf=|usr=}}{{25772353}} gab.com Text A lupus-associated Mac-1 variant has defects in integrin allostery and interaction with ligands under force JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25772353 #FOAvip Leukocyte CD18 integrins increase affinity for ligand via transmission of allosteric signals to and from their ligand binding ?I-domain. Mechanical forces induce allosteric changes that paradoxically slow dissociation by increasing integrin/ligand bond lifetimes, referred to as catch bonds. Like LFA-1, Mac-1 (ITGAM) forms catch bonds with its ligands. However, the Mac-1 rs1143679 (R77H) variant, located in the ?-propeller domain and significantly associated with systemic lupus erythematosus risk, exhibits a marked impairment in 2D ligand affinity and affinity maturation under mechanical force. Targeted mutations and activating antibodies reveal that the failure in Mac-1 R77H allostery is rescued by induction of cytoplasmic tail separation and full integrin extension. These findings demonstrate roles for R77, and the ?-propeller in which it resides, in force-induced allostery relay and integrin bond stabilization, suggesting that these defects may have pathological consequences as the Mac-1 R77H variant associates with increased lupus susceptibility. Twit Text FOAVip A lupus-associated Mac-1 variant has defects in integrin allostery and interaction with ligands under force ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25772353 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25772353 #FOAvip English Wikipedia <ref>{{Cite pmid|25772353}}</ref> A lupus-associated Mac-1 variant has defects in integrin allostery and interaction with ligands under force #MMPMID25772353 Rosetti F; Chen Y; Sen M; Thayer E; Azcutia V; Herter J; Luscinskas F; Cullere X; Zhu C; Mayadas T Cell Rep 2015[Mar]; 10 (10): 1655-64 PMID25772353show ga Leukocyte CD18 integrins increase affinity for ligand via transmission of allosteric signals to and from their ligand binding ?I-domain. Mechanical forces induce allosteric changes that paradoxically slow dissociation by increasing integrin/ligand bond lifetimes, referred to as catch bonds. Like LFA-1, Mac-1 (ITGAM) forms catch bonds with its ligands. However, the Mac-1 rs1143679 (R77H) variant, located in the ?-propeller domain and significantly associated with systemic lupus erythematosus risk, exhibits a marked impairment in 2D ligand affinity and affinity maturation under mechanical force. Targeted mutations and activating antibodies reveal that the failure in Mac-1 R77H allostery is rescued by induction of cytoplasmic tail separation and full integrin extension. These findings demonstrate roles for R77, and the ?-propeller in which it resides, in force-induced allostery relay and integrin bond stabilization, suggesting that these defects may have pathological consequences as the Mac-1 R77H variant associates with increased lupus susceptibility. äA lupus-associated Mac-1 variant has defects in integrin allostery and(epmc).pdf DeepDyve Pubget Overpricing