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10.1212/WNL.0000000000001923 http://scihub22266oqcxt.onion/10.1212/WNL.0000000000001923 C4567460!4567460!26296519     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurology 2015 ; 85 (11): 927-34 Nephropedia Template TP {{tp|p=26296519|t=2015. Cerebral microbleeds and postthrombolysis intracerebral hemorrhage risk: Updated meta-analysis |pdf=|usr=}}{{26296519}} gab.com Text Cerebral microbleeds and postthrombolysis intracerebral hemorrhage risk: Updated meta-analysis JO: Neurology http://www.kidney.de/pget.php?&tw=1&pmid=26296519 #FOAvip Objective:: We performed a systematic review and meta-analysis to assess whether the presence of cerebral microbleeds (CMBs) on pretreatment MRI scans of patients with acute ischemic stroke treated with thrombolysis is associated with an increased risk of symptomatic intracerebral hemorrhage (ICH). Methods:: We searched PubMed for relevant studies and calculated pooled odds ratios (ORs) for symptomatic ICH, using the Mantel?Haenszel fixed-effects method, among individuals with vs without CMBs on pretreatment MRI scans. To minimize potential bias, sensitivity analysis was performed including studies providing data on patients treated only with IV thrombolysis. Results:: Ten eligible studies including 2,028 patients were pooled in meta-analysis. The overall prevalence of CMBs was 23.3%. Among patients with CMBs, 40 of 472 (8.5%; 95% confidence interval [CI]: 6.1%?11.4%) experienced a symptomatic ICH after thrombolysis compared with 61 of 1,556 patients (3.9%; 95% CI: 3%?5%) without CMBs. The pooled OR of ICH across all studies was 2.26 (95% CI: 1.46?3.49; p < 0.0001). Eight studies, including 1,704 patients (n = 401 with CMBs), provided data on patients treated with IV thrombolysis only; OR for the presence of CMBs and the development of symptomatic ICH was 2.87 (95% CI: 1.76?4.69; p < 0.0001). Conclusions:: Our meta-analysis of the available published data demonstrates an increased risk of symptomatic ICH after thrombolysis for acute ischemic stroke in patients with CMBs. However, we cannot fully exclude bias or confounding, so our results should be considered hypothesis-generating. Detecting CMBs should not prevent thrombolytic treatment based on present evidence. Further analyses, taking into account CMB number and location, as well as measures of functional outcome, are needed. Twit Text FOAVip Cerebral microbleeds and postthrombolysis intracerebral hemorrhage risk: Updated meta-analysis ????Neurology http://www.kidney.de/pget.php?&tw=1&pmid=26296519 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26296519 #FOAvip English Wikipedia <ref>{{Cite pmid|26296519}}</ref> Cerebral microbleeds and postthrombolysis intracerebral hemorrhage risk: Updated meta-analysis #MMPMID26296519 Charidimou A; Shoamanesh A; Wilson D; Gang Q; Fox Z; Jäger HR; Benavente OR; Werring DJ Neurology 2015[Sep]; 85 (11): 927-34 PMID26296519show ga Objective:: We performed a systematic review and meta-analysis to assess whether the presence of cerebral microbleeds (CMBs) on pretreatment MRI scans of patients with acute ischemic stroke treated with thrombolysis is associated with an increased risk of symptomatic intracerebral hemorrhage (ICH). Methods:: We searched PubMed for relevant studies and calculated pooled odds ratios (ORs) for symptomatic ICH, using the Mantel?Haenszel fixed-effects method, among individuals with vs without CMBs on pretreatment MRI scans. To minimize potential bias, sensitivity analysis was performed including studies providing data on patients treated only with IV thrombolysis. Results:: Ten eligible studies including 2,028 patients were pooled in meta-analysis. The overall prevalence of CMBs was 23.3%. Among patients with CMBs, 40 of 472 (8.5%; 95% confidence interval [CI]: 6.1%?11.4%) experienced a symptomatic ICH after thrombolysis compared with 61 of 1,556 patients (3.9%; 95% CI: 3%?5%) without CMBs. The pooled OR of ICH across all studies was 2.26 (95% CI: 1.46?3.49; p < 0.0001). Eight studies, including 1,704 patients (n = 401 with CMBs), provided data on patients treated with IV thrombolysis only; OR for the presence of CMBs and the development of symptomatic ICH was 2.87 (95% CI: 1.76?4.69; p < 0.0001). Conclusions:: Our meta-analysis of the available published data demonstrates an increased risk of symptomatic ICH after thrombolysis for acute ischemic stroke in patients with CMBs. However, we cannot fully exclude bias or confounding, so our results should be considered hypothesis-generating. Detecting CMBs should not prevent thrombolytic treatment based on present evidence. Further analyses, taking into account CMB number and location, as well as measures of functional outcome, are needed. äCerebral microbleeds and postthrombolysis intracerebral hemorrhage ris(epmc).pdf DeepDyve Pubget Overpricing