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2015 ; 48
(4
): 225-32
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Accuracy of computer-aided ultrasound as compared with magnetic resonance imaging
in the evaluation of nonalcoholic fatty liver disease in obese and eutrophic
adolescents
#MMPMID26379321
do Nascimento JH
; Soder RB
; Epifanio M
; Baldisserotto M
Radiol Bras
2015[Jul]; 48
(4
): 225-32
PMID26379321
show ga
OBJECTIVE: To compare the accuracy of computer-aided ultrasound (US) and magnetic
resonance imaging (MRI) by means of hepatorenal gradient analysis in the
evaluation of nonalcoholic fatty liver disease (NAFLD) in adolescents. MATERIALS
AND METHODS: This prospective, cross-sectional study evaluated 50 adolescents
(aged 11-17 years), including 24 obese and 26 eutrophic individuals. All
adolescents underwent computer-aided US, MRI, laboratory tests, and
anthropometric evaluation. Sensitivity, specificity, positive and negative
predictive values and accuracy were evaluated for both imaging methods, with
subsequent generation of the receiver operating characteristic (ROC) curve and
calculation of the area under the ROC curve to determine the most appropriate
cutoff point for the hepatorenal gradient in order to predict the degree of
steatosis, utilizing MRI results as the gold-standard. RESULTS: The obese group
included 29.2% girls and 70.8% boys, and the eutrophic group, 69.2% girls and
30.8% boys. The prevalence of NAFLD corresponded to 19.2% for the eutrophic group
and 83% for the obese group. The ROC curve generated for the hepatorenal gradient
with a cutoff point of 13 presented 100% sensitivity and 100% specificity. As the
same cutoff point was considered for the eutrophic group, false-positive results
were observed in 9.5% of cases (90.5% specificity) and false-negative results in
0% (100% sensitivity). CONCLUSION: Computer-aided US with hepatorenal gradient
calculation is a simple and noninvasive technique for semiquantitative evaluation
of hepatic echogenicity and could be useful in the follow-up of adolescents with
NAFLD, population screening for this disease as well as for clinical studies.