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2015 ; 48
(4
): 216-9
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Magnetic resonance imaging and BMB score in the evaluation of bone involvement in
Gaucher s disease patients
#MMPMID26379319
de Mello RA
; Mello MB
; Pessanha LB
Radiol Bras
2015[Jul]; 48
(4
): 216-9
PMID26379319
show ga
OBJECTIVE: To evaluate by magnetic resonance imaging changes in bone marrow of
patients undergoing treatment for type I Gaucher's disease. MATERIALS AND
METHODS: Descriptive, cross-sectional study of Gaucher's disease patients
submitted to 3 T magnetic resonance imaging of femurs and lumbar spine. The
images were blindly reviewed and the findings were classified according to the
semiquantitative bone marrow burden (BMB) scoring system. RESULTS: All of the
seven evaluated patients (three men and four women) presented signs of bone
marrow infiltration. Osteonecrosis of the femoral head was found in three
patients, Erlenmeyer flask deformity in five, and no patient had vertebral body
collapse. The mean BMB score was 11, ranging from 9 to 14. CONCLUSION: Magnetic
resonance imaging is currently the method of choice for assessing bone
involvement in Gaucher's disease in adults due to its high sensitivity to detect
both focal and diffuse bone marrow changes, and the BMB score is a simplified
method for semiquantitative analysis, without depending on advanced sequences or
sophisticated hardware, allowing for the classification of the disease extent and
assisting in the treatment monitoring.