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10.1590/0100-3984.2014.0068

http://scihub22266oqcxt.onion/10.1590/0100-3984.2014.0068
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pmid26379319
      Radiol+Bras 2015 ; 48 (4 ): 216-9
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  • Magnetic resonance imaging and BMB score in the evaluation of bone involvement in Gaucher s disease patients #MMPMID26379319
  • de Mello RA ; Mello MB ; Pessanha LB
  • Radiol Bras 2015[Jul]; 48 (4 ): 216-9 PMID26379319 show ga
  • OBJECTIVE: To evaluate by magnetic resonance imaging changes in bone marrow of patients undergoing treatment for type I Gaucher's disease. MATERIALS AND METHODS: Descriptive, cross-sectional study of Gaucher's disease patients submitted to 3 T magnetic resonance imaging of femurs and lumbar spine. The images were blindly reviewed and the findings were classified according to the semiquantitative bone marrow burden (BMB) scoring system. RESULTS: All of the seven evaluated patients (three men and four women) presented signs of bone marrow infiltration. Osteonecrosis of the femoral head was found in three patients, Erlenmeyer flask deformity in five, and no patient had vertebral body collapse. The mean BMB score was 11, ranging from 9 to 14. CONCLUSION: Magnetic resonance imaging is currently the method of choice for assessing bone involvement in Gaucher's disease in adults due to its high sensitivity to detect both focal and diffuse bone marrow changes, and the BMB score is a simplified method for semiquantitative analysis, without depending on advanced sequences or sophisticated hardware, allowing for the classification of the disease extent and assisting in the treatment monitoring.
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