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10.1371/journal.pone.0137279 http://scihub22266oqcxt.onion/10.1371/journal.pone.0137279 C4567284!4567284!26360059     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2015 ; 10 (9): ä Nephropedia Template TP {{tp|p=26360059|t=2015. To Hit or Not to Hit, That Is the Question ? Genome-wide Structure-Based Druggability Predictions for Pseudomonas aeruginosa Proteins |pdf=|usr=}}{{26360059}} gab.com Text To Hit or Not to Hit, That Is the Question Genome-wide Structure-Based Druggability Predictions for Pseudomonas aeruginosa Proteins JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26360059 #FOAvip Pseudomonas aeruginosa is a Gram-negative bacterium known to cause opportunistic infections in immune-compromised or immunosuppressed individuals that often prove fatal. New drugs to combat this organism are therefore sought after. To this end, we subjected the gene products of predicted perturbative genes to structure-based druggability predictions using DrugPred. Making this approach suitable for large-scale predictions required the introduction of new methods for calculation of descriptors, development of a workflow to identify suitable pockets in homologous proteins and establishment of criteria to obtain valid druggability predictions based on homologs. We were able to identify 29 perturbative proteins of P. aeruginosa that may contain druggable pockets, including some of them with no or no drug-like inhibitors deposited in ChEMBL. These proteins form promising novel targets for drug discovery against P. aeruginosa. Twit Text FOAVip To Hit or Not to Hit, That Is the Question Genome-wide Structure-Based Druggability Predictions for Pseudomonas aeruginosa Proteins ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26360059 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26360059 #FOAvip English Wikipedia <ref>{{Cite pmid|26360059}}</ref> To Hit or Not to Hit, That Is the Question ? Genome-wide Structure-Based Druggability Predictions for Pseudomonas aeruginosa Proteins #MMPMID26360059 Sarkar A; Brenk R PLoS One 2015[]; 10 (9): ä PMID26360059show ga Pseudomonas aeruginosa is a Gram-negative bacterium known to cause opportunistic infections in immune-compromised or immunosuppressed individuals that often prove fatal. New drugs to combat this organism are therefore sought after. To this end, we subjected the gene products of predicted perturbative genes to structure-based druggability predictions using DrugPred. Making this approach suitable for large-scale predictions required the introduction of new methods for calculation of descriptors, development of a workflow to identify suitable pockets in homologous proteins and establishment of criteria to obtain valid druggability predictions based on homologs. We were able to identify 29 perturbative proteins of P. aeruginosa that may contain druggable pockets, including some of them with no or no drug-like inhibitors deposited in ChEMBL. These proteins form promising novel targets for drug discovery against P. aeruginosa. äTo Hit or Not to Hit, That Is the Question ? Genome-wide Structure-Bas(epmc).pdf DeepDyve Pubget Overpricing