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10.1080/10543406.2014.920343 http://scihub22266oqcxt.onion/10.1080/10543406.2014.920343 C4566885!4566885!24918730     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biopharm+Stat 2015 ; 25 (5): 939-57 Nephropedia Template TP {{tp|p=24918730|t=2015. Point and Interval Estimators of the Target Dose in Clinical Dose-Finding Studies with Active Control |pdf=|usr=}}{{24918730}} gab.com Text Point and Interval Estimators of the Target Dose in Clinical Dose-Finding Studies with Active Control JO: J Biopharm Stat http://www.kidney.de/pget.php?&tw=1&pmid=24918730 #FOAvip In a clinical dose finding study with active control a new drug with several dose levels is compared with an active comparator drug. The main focus of such studies often lies on the estimation of a target dose that leads to the same efficacy as the control. This article investigates the finite sample properties of the maximum likelihood estimation of the target dose and compares several approaches for constructing corresponding confidence intervals under the assumption of a linear dose-response curve and normal error terms. Furthermore, the impact of deviations from the model assumptions regarding the error distribution is explored. Twit Text FOAVip Point and Interval Estimators of the Target Dose in Clinical Dose-Finding Studies with Active Control ????J Biopharm Stat http://www.kidney.de/pget.php?&tw=1&pmid=24918730 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24918730 #FOAvip English Wikipedia <ref>{{Cite pmid|24918730}}</ref> Point and Interval Estimators of the Target Dose in Clinical Dose-Finding Studies with Active Control #MMPMID24918730 Helms HJ; Benda N; Friede T J Biopharm Stat 2015[Sep]; 25 (5): 939-57 PMID24918730show ga In a clinical dose finding study with active control a new drug with several dose levels is compared with an active comparator drug. The main focus of such studies often lies on the estimation of a target dose that leads to the same efficacy as the control. This article investigates the finite sample properties of the maximum likelihood estimation of the target dose and compares several approaches for constructing corresponding confidence intervals under the assumption of a linear dose-response curve and normal error terms. Furthermore, the impact of deviations from the model assumptions regarding the error distribution is explored. äPoint and Interval Estimators of the Target Dose in Clinical Dose-Find(epmc).pdf DeepDyve Pubget Overpricing