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10.1074/jbc.M115.670661

http://scihub22266oqcxt.onion/10.1074/jbc.M115.670661
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C4566231!4566231!26231209
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suck abstract from ncbi


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pmid26231209      J+Biol+Chem 2015 ; 290 (37): 22570-80
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  • C1q Protein Binds to the Apoptotic Nucleolus and Causes C1 Protease Degradation of Nucleolar Proteins* #MMPMID26231209
  • Cai Y; Teo BHD; Yeo JG; Lu J
  • J Biol Chem 2015[Sep]; 290 (37): 22570-80 PMID26231209show ga
  • Background: C1q binds to apoptotic cells, but the binding sites are unclear.Results: C1q binds to the nucleolus in advanced apoptotic cells, and the C1q-associated C1r/C1s proteases degrade nucleolar proteins.Conclusion: C1q recruits C1r/C1s to specific structures in dead cells, leading to cellular antigen degradation.Significance: This helps to explain why C1r/C1s and C1q deficiency cause autoimmunity.
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