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10.1074/jbc.M115.670661 http://scihub22266oqcxt.onion/10.1074/jbc.M115.670661 C4566231!4566231 !26231209     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26231209 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2015 ; 290 (37 ): 22570-80 Nephropedia Template TP {{tp|p=26231209 |t=2015. C1q protein binds to the apoptotic nucleolus and causes C1 protease degradation of nucleolar proteins |pdf=|usr=}}{{26231209 }} gab.com Text C1q protein binds to the apoptotic nucleolus and causes C1 protease degradation of nucleolar proteins JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26231209 #FOAvip In infection, complement C1q recognizes pathogen-congregated antibodies and elicits complement activation. Among endogenous ligands, C1q binds to DNA and apoptotic cells, but whether C1q binds to nuclear DNA in apoptotic cells remains to be investigated. With UV irradiation-induced apoptosis, C1q initially bound to peripheral cellular regions in early apoptotic cells. By 6 h, binding concentrated in the nuclei to the nucleolus but not the chromatins. When nucleoli were isolated from non-apoptotic cells, C1q also bound to these structures. In vivo, C1q exists as the C1 complex (C1qC1r2C1s2), and C1q binding to ligands activates the C1r/C1s proteases. Incubation of nucleoli with C1 caused degradation of the nucleolar proteins nucleolin and nucleophosmin 1. This was inhibited by the C1 inhibitor. The nucleoli are abundant with autoantigens. C1q binding and C1r/C1s degradation of nucleolar antigens during cell apoptosis potentially reduces autoimmunity. These findings help us to understand why genetic C1q and C1r/C1s deficiencies cause systemic lupus erythematosus. Twit Text FOAVip C1q protein binds to the apoptotic nucleolus and causes C1 protease degradation of nucleolar proteins ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26231209 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26231209 #FOAvip English Wikipedia <ref>{{Cite pmid|26231209 }}</ref> C1q protein binds to the apoptotic nucleolus and causes C1 protease degradation of nucleolar proteins #MMPMID26231209 Cai Y ; Teo BH ; Yeo JG ; Lu J J Biol Chem 2015[Sep]; 290 (37 ): 22570-80 PMID26231209 show ga In infection, complement C1q recognizes pathogen-congregated antibodies and elicits complement activation. Among endogenous ligands, C1q binds to DNA and apoptotic cells, but whether C1q binds to nuclear DNA in apoptotic cells remains to be investigated. With UV irradiation-induced apoptosis, C1q initially bound to peripheral cellular regions in early apoptotic cells. By 6 h, binding concentrated in the nuclei to the nucleolus but not the chromatins. When nucleoli were isolated from non-apoptotic cells, C1q also bound to these structures. In vivo, C1q exists as the C1 complex (C1qC1r2C1s2), and C1q binding to ligands activates the C1r/C1s proteases. Incubation of nucleoli with C1 caused degradation of the nucleolar proteins nucleolin and nucleophosmin 1. This was inhibited by the C1 inhibitor. The nucleoli are abundant with autoantigens. C1q binding and C1r/C1s degradation of nucleolar antigens during cell apoptosis potentially reduces autoimmunity. These findings help us to understand why genetic C1q and C1r/C1s deficiencies cause systemic lupus erythematosus. |*Ultraviolet Rays [MESH] |Apoptosis/*radiation effects [MESH] |Cell Nucleolus/*metabolism [MESH] |Complement C1q/*metabolism [MESH] |Complement C1r/*metabolism [MESH] |Complement C1s/*metabolism [MESH] |HeLa Cells [MESH] |Humans [MESH] |Nuclear Proteins/*metabolism [MESH] |Nucleolin [MESH] |Nucleophosmin [MESH] |Phosphoproteins/*metabolism [MESH] |Proteolysis/*radiation effects [MESH]C1q protein binds to the apoptotic nucleolus and causes C1 protease de(epmc).pdf DeepDyve Pubget Overpricing