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10.1074/jbc.M115.658104

http://scihub22266oqcxt.onion/10.1074/jbc.M115.658104
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suck abstract from ncbi


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pmid26245896      J+Biol+Chem 2015 ; 290 (37): 22485-93
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  • Karyopherin ? 3 and Karyopherin ? 4 Proteins Mediate the Nuclear Import of Methyl-CpG Binding Protein 2* #MMPMID26245896
  • Baker SA; Lombardi LM; Zoghbi HY
  • J Biol Chem 2015[Sep]; 290 (37): 22485-93 PMID26245896show ga
  • Background: MeCP2 is a key nuclear protein that binds methylated DNA to regulate the chromatin state.Results: KPNA3 and KPNA4 bind to overlapping domains within MeCP2 to traffic it into the nucleus.Conclusion: KPNA3 permits the nuclear localization of truncated forms of MeCP2, reconciling discrepancies between predictions and experimental observations.Significance: Understanding the mechanism of MeCP2 nuclear import is critical for analyzing genotype-phenotype correlations in patients with Rett syndrome.
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