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10.1038/srep13886 http://scihub22266oqcxt.onion/10.1038/srep13886 C4566081!4566081 !26358827     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26358827 &cmd=llinks): Failed to open stream: HTTP request failed! 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Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous |pdf=|usr=}}{{26358827 }} gab.com Text Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26358827 #FOAvip Given the importance of monocytes in pathogenesis of infectious and other inflammatory disorders, delineating functional and phenotypic characterization of monocyte subsets has emerged as a critical requirement. Although human monocytes have been subdivided into three different populations based on surface expression of CD14 and CD16, published reports suffer from contradictions with respect to subset phenotypes and function. This has been attributed to discrepancies in reliable gating strategies for flow cytometric characterization and purification protocols contributing to significant changes in receptor expression. By using a combination of multicolour flow cytometry and a high-dimensional automated clustering algorithm to confirm robustness of gating strategy and analysis of ex-vivo activation of whole blood with LPS we demonstrate the following: a. 'Classical' monocytes are phagocytic with no inflammatory attributes, b. 'Non-classical' subtype display 'inflammatory' characteristics on activation and display properties for antigen presentation and c. 'Intermediate' subtype that constitutes a very small percentage in circulation (under physiological conditions) appear to be transitional monocytes that display both phagocytic and inflammatory function. Analysis of blood from patients with Sepsis, a pathogen driven acute inflammatory disease and Systemic Lupus Erythmatosus (SLE), a chronic inflammatory disorder validated the broad conclusions drawn in the study. Twit Text FOAVip Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26358827 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26358827 #FOAvip English Wikipedia <ref>{{Cite pmid|26358827 }}</ref> Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous #MMPMID26358827 Mukherjee R ; Kanti Barman P ; Kumar Thatoi P ; Tripathy R ; Kumar Das B ; Ravindran B Sci Rep 2015[Sep]; 5 (ä): 13886 PMID26358827 show ga Given the importance of monocytes in pathogenesis of infectious and other inflammatory disorders, delineating functional and phenotypic characterization of monocyte subsets has emerged as a critical requirement. Although human monocytes have been subdivided into three different populations based on surface expression of CD14 and CD16, published reports suffer from contradictions with respect to subset phenotypes and function. This has been attributed to discrepancies in reliable gating strategies for flow cytometric characterization and purification protocols contributing to significant changes in receptor expression. By using a combination of multicolour flow cytometry and a high-dimensional automated clustering algorithm to confirm robustness of gating strategy and analysis of ex-vivo activation of whole blood with LPS we demonstrate the following: a. 'Classical' monocytes are phagocytic with no inflammatory attributes, b. 'Non-classical' subtype display 'inflammatory' characteristics on activation and display properties for antigen presentation and c. 'Intermediate' subtype that constitutes a very small percentage in circulation (under physiological conditions) appear to be transitional monocytes that display both phagocytic and inflammatory function. Analysis of blood from patients with Sepsis, a pathogen driven acute inflammatory disease and Systemic Lupus Erythmatosus (SLE), a chronic inflammatory disorder validated the broad conclusions drawn in the study. |Antigens, Surface/metabolism [MESH] |Biomarkers [MESH] |Flow Cytometry [MESH] |Humans [MESH] |Immunophenotyping/methods [MESH] |Inflammation/immunology/metabolism [MESH] |Lupus Erythematosus, Systemic/*immunology/*metabolism [MESH] |Monocytes/*immunology/*metabolism [MESH] |Phenotype [MESH]Non-Classical monocytes display inflammatory features: Validation in S(epmc).pdf DeepDyve Pubget Overpricing