Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1165/rcmb.2014-0476TR http://scihub22266oqcxt.onion/10.1165/rcmb.2014-0476TR C4566071!4566071!25938935     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Respir+Cell+Mol+Biol 2015 ; 53 (3): 285-90 Nephropedia Template TP {{tp|p=25938935|t=2015. Circadian Clock?Coupled Lung Cellular and Molecular Functions in Chronic Airway Diseases |pdf=|usr=}}{{25938935}} gab.com Text Circadian Clock Coupled Lung Cellular and Molecular Functions in Chronic Airway Diseases JO: Am J Respir Cell Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25938935 #FOAvip Airway diseases are associated with abnormal circadian rhythms of lung function, reflected in daily changes of airway caliber, airway resistance, respiratory symptoms, and abnormal immune-inflammatory responses. Circadian rhythms are generated at the cellular level by an autoregulatory feedback loop of interlocked transcription factors collectively referred to as clock genes. The molecular clock is altered by cigarette smoke, LPS, and bacterial and viral infections in mouse and human lungs and in patients with chronic airway diseases. Stress-mediated post-translational modification of molecular clock proteins, brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1 (BMAL1) and PERIOD 2, is associated with a reduction in the activity/level of the deacetylase sirtuin 1 (SIRT1). Similarly, the levels of the nuclear receptor REV-ERB? and retinoic acid receptor?related orphan receptor ? (ROR ?), critical regulators of Bmal1 expression, are altered by environmental stresses. Molecular clock dysfunction is implicated in immune and inflammatory responses, DNA damage response, and cellular senescence. The molecular clock in the lung also regulates the timing of glucocorticoid sensitivity and phasic responsiveness to inflammation. Herein, we review our current understanding of clock-controlled cellular and molecular functions in the lungs, the impact of clock dysfunction in chronic airway disease, and the response of the pulmonary clock to different environmental perturbations. Furthermore, we discuss the evidence for candidate signaling pathways, such as the SIRT1?BMAL1?REV-ERB? axis, as novel targets for chronopharmacological management of chronic airway diseases. Twit Text FOAVip Circadian Clock Coupled Lung Cellular and Molecular Functions in Chronic Airway Diseases ????Am J Respir Cell Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25938935 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25938935 #FOAvip English Wikipedia <ref>{{Cite pmid|25938935}}</ref> Circadian Clock?Coupled Lung Cellular and Molecular Functions in Chronic Airway Diseases #MMPMID25938935 Sundar IK; Yao H; Sellix MT; Rahman I Am J Respir Cell Mol Biol 2015[Sep]; 53 (3): 285-90 PMID25938935show ga Airway diseases are associated with abnormal circadian rhythms of lung function, reflected in daily changes of airway caliber, airway resistance, respiratory symptoms, and abnormal immune-inflammatory responses. Circadian rhythms are generated at the cellular level by an autoregulatory feedback loop of interlocked transcription factors collectively referred to as clock genes. The molecular clock is altered by cigarette smoke, LPS, and bacterial and viral infections in mouse and human lungs and in patients with chronic airway diseases. Stress-mediated post-translational modification of molecular clock proteins, brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1 (BMAL1) and PERIOD 2, is associated with a reduction in the activity/level of the deacetylase sirtuin 1 (SIRT1). Similarly, the levels of the nuclear receptor REV-ERB? and retinoic acid receptor?related orphan receptor ? (ROR ?), critical regulators of Bmal1 expression, are altered by environmental stresses. Molecular clock dysfunction is implicated in immune and inflammatory responses, DNA damage response, and cellular senescence. The molecular clock in the lung also regulates the timing of glucocorticoid sensitivity and phasic responsiveness to inflammation. Herein, we review our current understanding of clock-controlled cellular and molecular functions in the lungs, the impact of clock dysfunction in chronic airway disease, and the response of the pulmonary clock to different environmental perturbations. Furthermore, we discuss the evidence for candidate signaling pathways, such as the SIRT1?BMAL1?REV-ERB? axis, as novel targets for chronopharmacological management of chronic airway diseases. äCircadian Clock?Coupled Lung Cellular and Molecular Functions in Chron(epmc).pdf DeepDyve Pubget Overpricing